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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fko 20K Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fko 20KCyclin-dependent kinase 2 2.7.11.22 1.049
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.956
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.954
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.808
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.774
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.767
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.719
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.716
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.714
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.713
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.692
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.691
3fzr 3JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.690
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.688
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.685
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.684
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.675
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.675
3uo5 0BXAurora kinase A 2.7.11.1 0.674
1pxk CK3Cyclin-dependent kinase 2 2.7.11.22 0.668
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.668
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.668
3unj 0BXCyclin-dependent kinase 2 2.7.11.22 0.667
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.667
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.666
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.666
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.665
2etm 7PYFocal adhesion kinase 1 2.7.10.2 0.663
4dea NHIAurora kinase A 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.659
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.658
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.658
3et7 349Protein-tyrosine kinase 2-beta 2.7.10.2 0.655
4bbf O19Tyrosine-protein kinase JAK2 / 0.654
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.654
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.652
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.651
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.651
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.650