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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dt8 ADN APH(2'')-Id

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dt8 ADNAPH(2'')-Id / 0.801
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.709
4dta ADNAPH(2'')-Id / 0.705
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.700
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.691
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.689
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.685
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.683
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.680
4dca ADPAminoglycoside phosphotransferase / 0.679
4fic 0ULProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.679
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.678
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.675
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.672
3w6h AZMCarbonic anhydrase 1 4.2.1.1 0.672
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.669
3d5w ADPSerine/threonine-protein kinase PLK / 0.669
4mv4 ACPBiotin carboxylase 6.3.4.14 0.669
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.668
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.668
4ftc H6KSerine/threonine-protein kinase Chk1 2.7.11.1 0.667
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
4gyi ADPUncharacterized protein / 0.666
4q5h ANPProtein kinase OspG 2.7 0.666
4egi B2JHeat shock protein HSP 90-alpha / 0.663
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.663
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.662
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.662
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.662
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.662
2pup ADPMethylthioribose kinase 2.7.1.100 0.662
3w0n ANPHygromycin-B 4-O-kinase 2.7.1.163 0.662
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.662
1i44 ACPInsulin receptor 2.7.10.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.659
5ani ES4Cyclin-dependent kinase 2 2.7.11.22 0.659
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.658
3ac2 KSETyrosine-protein kinase Lck 2.7.10.2 0.658
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.657
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.657
2olc ADPMethylthioribose kinase 2.7.1.100 0.657
4j99 ACPFibroblast growth factor receptor 2 / 0.657
4blt APCNTPase P4 / 0.656
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.656
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
3ac1 KZITyrosine-protein kinase Lck 2.7.10.2 0.655
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.654
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.654
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.654
4ix6 ADPUncharacterized protein / 0.654
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.654
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.653
2yee 2ECHeat shock protein HSP 90-alpha / 0.653
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.653
4mv3 ACPBiotin carboxylase 6.3.4.14 0.653
4c2w ANPAurora kinase B-A 2.7.11.1 0.652
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.651
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.651
1zyd ATPeIF-2-alpha kinase GCN2 / 0.650
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.650
2pun ACPMethylthioribose kinase 2.7.1.100 0.650
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.650