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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c5o FAD Putative monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c5o FADPutative monooxygenase / 1.151
4usr FADMonooxygenase / 0.898
4usq FADPyridine nucleotide-disulfide oxidoreductase / 0.813
4opc FDAConserved Archaeal protein / 0.725
4k2x FADPolyketide oxygenase/hydroxylase / 0.719
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.715
4opd FDAConserved Archaeal protein / 0.715
3atq FDAConserved Archaeal protein / 0.712
4opi FDAConserved Archaeal protein / 0.712
3axb FADPutative oxidoreductase / 0.707
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.704
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.704
4opl FDAConserved Archaeal protein / 0.704
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.701
3lov FADProtoporphyrinogen oxidase / 0.697
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.691
3kpk FADSulfide-quinone reductase / 0.689
4k5r FADOxygenase / 0.689
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.687
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.685
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.685
5buk FADFADH2-dependent halogenase / 0.685
4b69 FADL-ornithine N(5)-monooxygenase / 0.684
4wct FADFructosyl amine:oxygen oxidoreductase / 0.683
2yg7 FADPutrescine oxidase / 0.682
3cty FADProbable thioredoxin reductase / 0.681
3ish FADThioredoxin reductase 1.8.1.9 0.681
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.681
4x4j FADPutative oxygenase / 0.681
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.679
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.679
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
1h81 FADPolyamine oxidase 1.5.3.14 0.677
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.676
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.675
4b65 FADL-ornithine N(5)-monooxygenase / 0.674
4jq9 FADDihydrolipoyl dehydrogenase / 0.674
4opg FDAConserved Archaeal protein / 0.674
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.674
5hhf FDAUDP-galactopyranose mutase / 0.674
2xvh FADPutative flavin-containing monooxygenase / 0.673
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.673
3rp8 FADFAD-dependent urate hydroxylase / 0.673
4z24 FADPutative GMC-type oxidoreductase R135 1 0.672
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.670
2vq7 FADPutative flavin-containing monooxygenase / 0.669
4bk2 FADProbable salicylate monooxygenase / 0.669
4ysh FADGlycine oxidase / 0.669
3atr FDAConserved Archaeal protein / 0.668
3bg7 FADPyranose 2-oxidase / 0.668
4ap1 FADSteroid monooxygenase / 0.668
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
3ukl FADUDP-galactopyranose mutase / 0.666
4eqr FADCoenzyme A disulfide reductase / 0.666
3s55 NADPutative short-chain dehydrogenase/reductase / 0.665
2rgj FADFlavin-containing monooxygenase / 0.663
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.663
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.663
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.662
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.662
1h83 FADPolyamine oxidase 1.5.3.14 0.661
4tlx FDAKtzI / 0.661
3f8r NAPNADH oxidase/thioredoxin reductase / 0.660
3p9u FADTetX family tetracycline inactivation enzyme / 0.660
4aos FADSteroid monooxygenase / 0.660
1nhr FADNADH peroxidase 1.11.1.1 0.658
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
4tm3 FADKtzI / 0.658
2q0k FADThioredoxin reductase 1.8.1.9 0.656
2xve FADPutative flavin-containing monooxygenase / 0.656
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.656
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.656
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.655
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.655
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.655
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.654
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.654
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.654
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.653
1xpq FADPolyamine oxidase FMS1 / 0.652
3cgb FADCoenzyme A disulfide reductase / 0.652
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.651
2eq7 NADDihydrolipoyl dehydrogenase / 0.651
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.650
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.650
1z6l FADPolyamine oxidase FMS1 / 0.650
2q0l FADThioredoxin reductase 1.8.1.9 0.650
2xlp FADPutative flavin-containing monooxygenase / 0.650
3pl8 FADPyranose 2-oxidase / 0.650
4bk3 FADProbable salicylate monooxygenase / 0.650