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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uix Q17 Serine/threonine-protein kinase pim-1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3uix Q17Serine/threonine-protein kinase pim-1 2.7.11.1 1.131
4lm5 Q17Serine/threonine-protein kinase pim-1 2.7.11.1 1.016
5auu LU2Death-associated protein kinase 1 2.7.11.1 0.680
3c4e C4ESerine/threonine-protein kinase pim-1 2.7.11.1 0.670
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.666
3elu SAMMethyltransferase / 0.666
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
2hru ADPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.662
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1wet GUNHTH-type transcriptional repressor PurR / 0.660
1xxj UNCUricase 1.7.3.3 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2d09 FLVBiflaviolin synthase CYP158A2 / 0.660
2oap ANPType II secretion system protein (GspE-2) / 0.660
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
2zs9 ADPPantothenate kinase 2.7.1.33 0.660
3cwq ADPParA family chromosome partitioning protein / 0.660
3f8p NADNADH oxidase/thioredoxin reductase / 0.660
3f8r NAPNADH oxidase/thioredoxin reductase / 0.660
3fzf ATPHeat shock cognate 71 kDa protein / 0.660
3u9d ATPActin, alpha skeletal muscle / 0.660
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.660
4e5l DBHPolymerase acidic protein / 0.660
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.660
4eh4 IRGMitogen-activated protein kinase 14 / 0.655
1xo2 FSECyclin-dependent kinase 6 2.7.11.22 0.654
3amy AGICasein kinase II subunit alpha 2.7.11.1 0.654
3qqh X0ACyclin-dependent kinase 2 2.7.11.22 0.654
3ty3 GGGHomoisocitrate dehydrogenase 1.1.1.87 0.654
4hlm 16STankyrase-2 2.4.2.30 0.650