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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3igo ANP Calmodulin-domain protein kinase 1, putative

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.929
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.761
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.750
3orp AGSSerine/threonine protein kinase / 0.747
3c4w ATPRhodopsin kinase / 0.745
3nie ANPMitogen-activated protein kinase / 0.735
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.731
3llt ANPProtein serine/threonine kinase-1 / 0.723
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.722
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.721
3ort AGSSerine/threonine protein kinase / 0.716
3t8o ATPRhodopsin kinase / 0.714
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.714
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.707
2wqe ADPAurora kinase A 2.7.11.1 0.706
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.706
2pyw ADPMethylthioribose kinase 2.7.1.100 0.705
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.705
5l8l ADPAurora kinase A 2.7.11.1 0.704
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.703
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.700
1ol6 ATPAurora kinase A 2.7.11.1 0.697
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.697
2pzp ACPFibroblast growth factor receptor 2 / 0.695
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
3a8w ATPProtein kinase C iota type 2.7.11.13 0.694
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.693
5drd ATPAurora kinase A 2.7.11.1 0.693
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.692
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.691
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.690
4c3r ACPAurora kinase A 2.7.11.1 0.689
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.687
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.686
5dnr ATPAurora kinase A 2.7.11.1 0.685
2pul ACPMethylthioribose kinase 2.7.1.100 0.684
4bn1 ADPAurora kinase A 2.7.11.1 0.684
4jrn ANPRhoptry kinase family protein / 0.684
5l8j ADPAurora kinase A 2.7.11.1 0.684
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.683
2pup ADPMethylthioribose kinase 2.7.1.100 0.682
3ork AGSSerine/threonine protein kinase / 0.682
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.682
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.682
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.682
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.682
3ori AGSSerine/threonine protein kinase / 0.680
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.679
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.679
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.677
1u54 ACPActivated CDC42 kinase 1 / 0.677
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.677
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.677
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.676
5dt3 ATPAurora kinase A 2.7.11.1 0.676
3c4z ADPRhodopsin kinase / 0.675
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.675
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.674
3c50 ADPRhodopsin kinase / 0.674
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.673
3qc9 ADPRhodopsin kinase / 0.673
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.673
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.673
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
4ceg ADPAurora kinase A 2.7.11.1 0.671
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.671
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.670
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.669
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
2pun ACPMethylthioribose kinase 2.7.1.100 0.668
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.668
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.668
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.668
5dn3 ATPAurora kinase A 2.7.11.1 0.668
1mq4 ADPAurora kinase A 2.7.11.1 0.667
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.667
2pz5 ACPFibroblast growth factor receptor 2 / 0.665
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.665
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.662
2dwb ANPAurora kinase A 2.7.11.1 0.662
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.662
4dee ADPAurora kinase A 2.7.11.1 0.662
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.661
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.660
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.660
3oro AGSSerine/threonine protein kinase / 0.660
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.659
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.659
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.659
5byl GCPBifunctional AAC/APH 2.3.1 0.659
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.658
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.658
5dr2 ATPAurora kinase A 2.7.11.1 0.658
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.657
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.657
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.657
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.656
4utd ACPAurora kinase A 2.7.11.1 0.656
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.655
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.655
3hav ATPAminoglycoside phosphotransferase / 0.655
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
2oli IOPBasic phospholipase A2 VRV-PL-VIIIa 3.1.1.4 0.654
2pui ADPMethylthioribose kinase 2.7.1.100 0.653
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.651
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4c3p ACPAurora kinase A 2.7.11.1 0.651
4qny ANPMitogen activated protein kinase, putative / 0.651
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.650
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.650
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.650
4n57 ADPAPH(2'')-Id / 0.650
5iqb GNPBifunctional AAC/APH 2.3.1 0.650