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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hko ANP Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.939
3t8o ATPRhodopsin kinase / 0.701
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.700
1ir3 ANPInsulin receptor 2.7.10.1 0.699
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.695
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.694
3ork AGSSerine/threonine protein kinase / 0.693
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.693
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.691
4o0u ADNAurora kinase A 2.7.11.1 0.691
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.688
3c50 ADPRhodopsin kinase / 0.685
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4dee ADPAurora kinase A 2.7.11.1 0.681
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.681
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.680
4qny ANPMitogen activated protein kinase, putative / 0.680
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.679
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.676
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.676
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.673
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.673
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.673
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
5dos ATPAurora kinase A 2.7.11.1 0.670
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.669
2zdg ADPD-alanine--D-alanine ligase / 0.669
3llt ANPProtein serine/threonine kinase-1 / 0.669
3orp AGSSerine/threonine protein kinase / 0.668
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
4o0w ADNAurora kinase A 2.7.11.1 0.668
1id0 ANPSensor protein PhoQ 2.7.13.3 0.667
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.667
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.666
5dt4 ATPAurora kinase A 2.7.11.1 0.666
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.665
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
5ckw ANPUncharacterized protein / 0.665
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.664
3ort AGSSerine/threonine protein kinase / 0.664
3ori AGSSerine/threonine protein kinase / 0.663
3qc9 ADPRhodopsin kinase / 0.663
4ysj ADPCalmodulin-like domain protein kinase / 0.663
5ce3 ADPProtein kinase YopO / 0.663
5dt3 ATPAurora kinase A 2.7.11.1 0.663
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.661
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.660
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.660
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.660
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.660
2dwb ANPAurora kinase A 2.7.11.1 0.659
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.659
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.658
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.658
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.656
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.656
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2olc ADPMethylthioribose kinase 2.7.1.100 0.655
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.655
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.654
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4a06 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.653
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
2yaa ATPDeath-associated protein kinase 2 / 0.652
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.652
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.651
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.651
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.651
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.651
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.650
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.650
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.650
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.650
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.650
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.650
4xlv ACPInsulin receptor 2.7.10.1 0.650