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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3a7j ADP Serine/threonine-protein kinase 24 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.945
3c50 ADPRhodopsin kinase / 0.770
2pyw ADPMethylthioribose kinase 2.7.1.100 0.758
3qc9 ADPRhodopsin kinase / 0.750
3t8o ATPRhodopsin kinase / 0.746
3c4z ADPRhodopsin kinase / 0.744
1mq4 ADPAurora kinase A 2.7.11.1 0.735
2dwb ANPAurora kinase A 2.7.11.1 0.735
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.735
3c4w ATPRhodopsin kinase / 0.732
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.732
3nie ANPMitogen-activated protein kinase / 0.717
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.714
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.713
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.713
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.699
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.699
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.698
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.698
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.694
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.693
4dee ADPAurora kinase A 2.7.11.1 0.693
5dr2 ATPAurora kinase A 2.7.11.1 0.692
5dos ATPAurora kinase A 2.7.11.1 0.691
2pui ADPMethylthioribose kinase 2.7.1.100 0.688
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.688
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.687
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.687
3bu5 ATPInsulin receptor 2.7.10.1 0.685
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
3c4x ATPRhodopsin kinase / 0.684
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.684
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.678
5l8k ADPAurora kinase A 2.7.11.1 0.678
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.677
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
1cm8 ANPMitogen-activated protein kinase 12 / 0.675
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.675
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.673
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.673
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.673
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.672
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.672
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.671
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.670
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.670
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.668
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.668
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.668
2pul ACPMethylthioribose kinase 2.7.1.100 0.667
3llt ANPProtein serine/threonine kinase-1 / 0.667
3oro AGSSerine/threonine protein kinase / 0.667
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.667
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.667
5l8l ADPAurora kinase A 2.7.11.1 0.667
2pun ACPMethylthioribose kinase 2.7.1.100 0.666
2py3 ACPFibroblast growth factor receptor 2 / 0.666
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.666
3q5i ANPProtein kinase, putative / 0.666
4o4d ATPKinase / 0.665
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.664
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.663
4qny ANPMitogen activated protein kinase, putative / 0.663
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.663
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.662
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.662
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.662
4n57 ADPAPH(2'')-Id / 0.662
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.661
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.661
4gyi ADPUncharacterized protein / 0.661
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.660
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.659
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.658
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.658
5dt3 ATPAurora kinase A 2.7.11.1 0.658
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.657
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
2yaa ATPDeath-associated protein kinase 2 / 0.657
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.656
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.656
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.655
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.654
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.654
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.653
2vqd AP2Biotin carboxylase 6.3.4.14 0.653
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.652
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.652
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.651
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.651
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.651
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.650
2pz5 ACPFibroblast growth factor receptor 2 / 0.650
3wo1 ADPAlanine--anticapsin ligase / 0.650
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650