Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yw9 NAP Enoyl-[acyl-carrier-protein] reductase [NADH]

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 1.119
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.875
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.796
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.785
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.770
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.769
3r3s NADPutative oxidoreductase / 0.767
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.767
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.764
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.756
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.756
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.754
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.744
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.743
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.743
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.738
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.738
1vrw NAIEnoyl-ACP reductase / 0.731
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.729
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.727
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.726
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.726
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.724
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.723
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.722
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.722
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.721
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.721
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.721
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.717
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.716
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.715
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.715
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.713
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.712
4dbz NDPPutative ketoacyl reductase 1.3.1 0.710
1pr9 NAPL-xylulose reductase 1.1.1.10 0.706
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.706
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.705
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.705
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.704
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.704
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.703
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.702
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.702
5jyd NADShort chain dehydrogenase / 0.702
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.701
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.701
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.701
5d2e NAPMlnE / 0.701
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.700
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.700
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.700
1oaa NAPSepiapterin reductase 1.1.1.153 0.697
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.697
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.696
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.695
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.694
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.694
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.693
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.693
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.693
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.692
2p5y NADUDP-glucose 4-epimerase / 0.691
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.691
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.691
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.691
3bmo NAPPteridine reductase / 0.689
4o1m NADEnoyl-acyl carrier reductase / 0.688
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.687
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.687
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.686
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.686
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.685
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.684
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.684
2wsb NADGalactitol dehydrogenase / 0.682
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.681
4b79 NADProbable short-chain dehydrogenase / 0.681
4j7u NAPSepiapterin reductase 1.1.1.153 0.681
4kwh NAPReductase homolog / 0.681
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.679
3qrw NDPPutative ketoacyl reductase 1.3.1 0.678
4hwk NAPSepiapterin reductase 1.1.1.153 0.677
3d3w NAPL-xylulose reductase 1.1.1.10 0.676
3p19 NDPPutative blue fluorescent protein / 0.676
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.676
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.675
4clo NAPPteridine reductase / 0.675
3ai2 NDPNADPH-sorbose reductase / 0.674
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.673
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.672
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.672
1iy8 NADLevodione reductase / 0.671
1w4z NAPPutative ketoacyl reductase 1.3.1 0.671
3h4v NAPPteridine reductase 1 1.5.1.33 0.671
1v35 NAIEnoyl-ACP reductase / 0.670
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.669
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.668
1x7g NAPPutative ketoacyl reductase 1.3.1 0.668
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.668
4bkq NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.668
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.668
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 0.668
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.667
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.667
3sju NDPKeto reductase / 0.667
4qec NAPElxO / 0.667
4qed NAPElxO / 0.667
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.666
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.666
4hxy NDPPlm1 / 0.666
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.665
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.665
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.665
3wds NADNADH-dependent quinuclidinone reductase / 0.665
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.665
1qyv NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.664
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.664
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.664
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.664
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.663
1rpn NDPGDP-mannose 4,6-dehydratase / 0.661
1sby NADAlcohol dehydrogenase 1.1.1.1 0.661
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.661
2p5u NADUDP-glucose 4-epimerase / 0.660
4bmv NAPShort-chain dehydrogenase / 0.660
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.660
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.660
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.659
1enp NADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic 1.3.1.9 0.659
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.659
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.659
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.659
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.657
2c29 NAPDihydroflavonol 4-reductase / 0.657
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.657
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.657
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.656
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.656
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.654
1zem NADXylitol dehydrogenase / 0.654
3icp NADNAD-dependent epimerase/dehydratase / 0.654
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.654
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.653
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.653
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.653
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.653
2yy7 NADL-threonine dehydrogenase / 0.653
3o26 NDPSalutaridine reductase / 0.653
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.653
4wec NADShort chain dehydrogenase / 0.653
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.652
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.652
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.651
2dte NAIGlucose 1-dehydrogenase related protein / 0.650
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.650
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.650