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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2y5d NAP 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 1.121
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.774
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.758
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.725
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.725
4pz2 NADAldehyde dehydrogenase 2-6 / 0.722
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.721
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.720
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.718
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.717
3iwj NADAminoaldehyde dehydrogenase / 0.716
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.715
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.714
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.713
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.712
4i8p NADAminoaldehyde dehydrogenase 1 / 0.712
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.709
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.707
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.707
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.705
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.704
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.703
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.703
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.701
4i8q NADPutative betaine aldehyde dehyrogenase / 0.701
4pxl NADAldehyde dehydrogenase3 / 0.701
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.700
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.700
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.699
4pt0 NADAldehyde dehydrogenase / 0.697
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.696
4pt3 NDPAldehyde dehydrogenase / 0.696
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.695
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.692
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.692
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.692
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.691
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.691
2jg7 NADAntiquitin / 0.690
4nmk NAPAldehyde dehydrogenase / 0.690
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.689
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.689
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.688
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.688
4i3v NADAldehyde dehydrogenase (NAD+) / 0.687
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.684
4nmj NAPAldehyde dehydrogenase / 0.682
4c3s NADAldehyde Dehydrogenase / 0.680
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.679
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.677
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.677
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.677
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.676
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.676
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.676
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.672
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.671
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.671
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.670
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.668
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.667
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.664
3b4w NADAldehyde dehydrogenase family protein / 0.664
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.662
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.661
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.660
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.657
4h73 NDPAldehyde dehydrogenase / 0.654
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.653
3haz NADBifunctional protein PutA / 0.652
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.652
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.652
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.651
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.651
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.650