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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qo7 ANP Ephrin type-A receptor 3 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.982
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.847
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.803
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.770
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.759
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.759
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.749
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.735
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.735
3c4z ADPRhodopsin kinase / 0.731
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.727
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.726
4ax8 ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.726
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.725
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.723
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.721
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.719
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.717
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.712
3pff ADPATP-citrate synthase 2.3.3.8 0.709
2wqe ADPAurora kinase A 2.7.11.1 0.705
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.703
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.703
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.702
5dr2 ATPAurora kinase A 2.7.11.1 0.700
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.698
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.697
4dee ADPAurora kinase A 2.7.11.1 0.697
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.697
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.696
4xlv ACPInsulin receptor 2.7.10.1 0.696
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.695
2pyw ADPMethylthioribose kinase 2.7.1.100 0.694
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.694
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.694
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.693
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.692
5drd ATPAurora kinase A 2.7.11.1 0.692
5dt3 ATPAurora kinase A 2.7.11.1 0.692
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.691
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.691
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.691
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.691
3b2t M33Fibroblast growth factor receptor 2 / 0.689
5dn3 ATPAurora kinase A 2.7.11.1 0.689
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.688
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.688
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.688
5dos ATPAurora kinase A 2.7.11.1 0.688
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.687
4c3r ACPAurora kinase A 2.7.11.1 0.686
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.684
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.684
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.683
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.683
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.683
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.682
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.681
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.681
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.681
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.681
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.680
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.680
4n57 ADPAPH(2'')-Id / 0.679
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.678
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.678
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.678
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.677
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.677
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.675
4q5h ANPProtein kinase OspG 2.7 0.675
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.674
3c50 ADPRhodopsin kinase / 0.674
4o1p ANPRibonuclease L / 0.674
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.674
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5ce3 ADPProtein kinase YopO / 0.673
3qc9 ADPRhodopsin kinase / 0.672
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.671
1m0w ANPGlutathione synthetase 6.3.2.3 0.670
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.670
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.670
1mq4 ADPAurora kinase A 2.7.11.1 0.668
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.668
3cly ACPFibroblast growth factor receptor 2 / 0.668
4ceg ADPAurora kinase A 2.7.11.1 0.668
3c4w ATPRhodopsin kinase / 0.667
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.666
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.666
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.665
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.664
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.664
2dwb ANPAurora kinase A 2.7.11.1 0.663
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.663
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.663
3bu5 ATPInsulin receptor 2.7.10.1 0.663
3ori AGSSerine/threonine protein kinase / 0.663
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1ir3 ANPInsulin receptor 2.7.10.1 0.662
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.662
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.662
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.662
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.662
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.661
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.660
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.659
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.659
4ix5 ANPUncharacterized protein / 0.659
4o0u ADNAurora kinase A 2.7.11.1 0.659
2olc ADPMethylthioribose kinase 2.7.1.100 0.658
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.657
1ol6 ATPAurora kinase A 2.7.11.1 0.656
3aq0 ISYSolanesyl diphosphate synthase 3, chloroplastic/mitochondrial 2.5.1.85 0.656
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.656
5iqd GNPBifunctional AAC/APH 2.3.1 0.656
1cm8 ANPMitogen-activated protein kinase 12 / 0.655
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.655
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.654
2dsc APRADP-sugar pyrophosphatase 3.6.1.13 0.654
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.654
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.654
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.653
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4gyi ADPUncharacterized protein / 0.653
2pup ADPMethylthioribose kinase 2.7.1.100 0.652
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.652
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.652
5dnr ATPAurora kinase A 2.7.11.1 0.652
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.651
1ss9 UPFLgtC / 0.650
2pzp ACPFibroblast growth factor receptor 2 / 0.650