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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qe0 NAP NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 1.184
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.903
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.895
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.832
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.818
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.803
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.802
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.798
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.795
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.787
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.785
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.784
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.784
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.777
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.766
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.765
4i8q NADPutative betaine aldehyde dehyrogenase / 0.762
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.752
2jg7 NADAntiquitin / 0.752
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.749
4i3v NADAldehyde dehydrogenase (NAD+) / 0.748
4nmk NAPAldehyde dehydrogenase / 0.746
4i3w NADAldehyde dehydrogenase (NAD+) / 0.745
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.744
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.740
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.740
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.736
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.734
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.733
2esd NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.731
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.730
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.729
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.728
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.725
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.724
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.723
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.723
3b4w NADAldehyde dehydrogenase family protein / 0.721
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.721
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.719
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.718
4pt0 NADAldehyde dehydrogenase / 0.715
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.711
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.710
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.710
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.709
4i8p NADAminoaldehyde dehydrogenase 1 / 0.709
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.709
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.705
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.702
4pxl NADAldehyde dehydrogenase3 / 0.701
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.699
4pz2 NADAldehyde dehydrogenase 2-6 / 0.696
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.695
4h73 NDPAldehyde dehydrogenase / 0.691
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.691
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.690
4nmj NAPAldehyde dehydrogenase / 0.689
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.686
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.684
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.680
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.680
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.680
4i9b NADPutative betaine aldehyde dehyrogenase / 0.678
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.675
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.673
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.670
1bi9 NADRetinal dehydrogenase 2 / 0.668
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.668
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.666
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.663
3qfs NAPNADPH--cytochrome P450 reductase / 0.658
3qft NAPNADPH--cytochrome P450 reductase / 0.658
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.656
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.655
3qe2 NAPNADPH--cytochrome P450 reductase / 0.654
4c3s NADAldehyde Dehydrogenase / 0.653