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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qcs ANP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.234
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.224
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.205
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.202
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.184
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.132
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.105
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.097
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.094
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.071
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 1.066
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.063
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.044
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.028
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.005
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.977
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.973
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.970
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.953
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.939
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.936
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.927
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.915
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.914
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.896
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.863
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.863
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.856
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.855
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.852
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.846
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.832
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.832
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.825
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.819
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.805
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.804
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.801
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.801
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.800
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.789
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.787
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.784
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.783
4ysj ADPCalmodulin-like domain protein kinase / 0.780
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.777
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.773
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.773
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.773
4dee ADPAurora kinase A 2.7.11.1 0.767
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.764
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.763
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.762
1cm8 ANPMitogen-activated protein kinase 12 / 0.761
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.760
3orm AGSSerine/threonine protein kinase / 0.758
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.756
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.756
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.756
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.755
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.753
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.750
3ori AGSSerine/threonine protein kinase / 0.749
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.745
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
5dt3 ATPAurora kinase A 2.7.11.1 0.743
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.742
5dn3 ATPAurora kinase A 2.7.11.1 0.742
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.741
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.740
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.740
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.739
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.739
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.737
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.737
3c4z ADPRhodopsin kinase / 0.736
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.735
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.734
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
1m0w ANPGlutathione synthetase 6.3.2.3 0.733
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.731
3c50 ADPRhodopsin kinase / 0.731
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.731
2pyw ADPMethylthioribose kinase 2.7.1.100 0.729
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.729
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.728
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.727
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.726
4ceg ADPAurora kinase A 2.7.11.1 0.726
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.725
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.722
3qc9 ADPRhodopsin kinase / 0.722
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.722
5iqb GNPBifunctional AAC/APH 2.3.1 0.722
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.721
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.721
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.720
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.720
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.720
4qny ANPMitogen activated protein kinase, putative / 0.717
5ce3 ADPProtein kinase YopO / 0.716
1mq4 ADPAurora kinase A 2.7.11.1 0.715
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.715
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.714
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.714
2pml ANPUncharacterized protein / 0.712
2pup ADPMethylthioribose kinase 2.7.1.100 0.711
3cly ACPFibroblast growth factor receptor 2 / 0.711
5drd ATPAurora kinase A 2.7.11.1 0.711
4n57 ADPAPH(2'')-Id / 0.710
4o4d ATPKinase / 0.710
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.709
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.707
5iqa GNPBifunctional AAC/APH 2.3.1 0.707
4utd ACPAurora kinase A 2.7.11.1 0.705
5iqf GDPBifunctional AAC/APH 2.3.1 0.705
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.704
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.703
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.703
4ork GDPBifunctional AAC/APH 2.3.1 0.702
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.701
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.700
3t8o ATPRhodopsin kinase / 0.700
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.699
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.699
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.698
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.698
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.697
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.696
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.696
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.695
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.695
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.695
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.693
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.692
2pul ACPMethylthioribose kinase 2.7.1.100 0.691
5dr2 ATPAurora kinase A 2.7.11.1 0.691
4ffr ATPUncharacterized protein / 0.690
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.689
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.689
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.689
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.689
5iqe GNPBifunctional AAC/APH 2.3.1 0.689
2pui ADPMethylthioribose kinase 2.7.1.100 0.688
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.686
5dos ATPAurora kinase A 2.7.11.1 0.686
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.685
2pun ACPMethylthioribose kinase 2.7.1.100 0.685
3rv4 ADPBiotin carboxylase 6.3.4.14 0.684
2x0q ATPAlcaligin biosynthesis protein / 0.683
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.682
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.681
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.681
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.681
5iqh GNPBifunctional AAC/APH 2.3.1 0.681
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.678
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.677
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.677
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.676
4o0w ADNAurora kinase A 2.7.11.1 0.676
1bxr ANPCarbamoyl-phosphate synthase large chain / 0.675
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.675
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.674
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.673
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.673
2vqd AP2Biotin carboxylase 6.3.4.14 0.673
4bn1 ADPAurora kinase A 2.7.11.1 0.673
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.673
3c4x ATPRhodopsin kinase / 0.672
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.672
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.671
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.671
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.670
3tdv GDPGentamicin resistance protein / 0.670
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.669
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.668
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.667
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
5byl GCPBifunctional AAC/APH 2.3.1 0.667
3ort AGSSerine/threonine protein kinase / 0.666
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.663
2w02 ATPAcsD / 0.663
4o0u ADNAurora kinase A 2.7.11.1 0.663
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.663
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.663
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.662
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.661
2osb AP5Adenylate kinase / 0.660
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.659
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.658
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.657
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.656
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.656
3w3d ATPActin, gamma-enteric smooth muscle / 0.656
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
1ol6 ATPAurora kinase A 2.7.11.1 0.655
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.655
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.655
1dej ATPMajor actin / 0.654
1px2 ATPSynapsin-1 / 0.654
2pz5 ACPFibroblast growth factor receptor 2 / 0.654
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.654
3wo0 ADPAlanine--anticapsin ligase / 0.654
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.654
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.653
2py3 ACPFibroblast growth factor receptor 2 / 0.653
3wnz ADPAlanine--anticapsin ligase / 0.653
4zgn ATPCell division cycle protein 123 / 0.653
4wud ANPDNA gyrase subunit B / 0.652
3dt4 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.651
4wh3 ATPN-acetylhexosamine 1-kinase 2.7.1.162 0.651
1mdu ATPActin, alpha skeletal muscle / 0.650
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.650
3orp AGSSerine/threonine protein kinase / 0.650
4o0s ADNAurora kinase A 2.7.11.1 0.650
4uxx ACPDiacylglycerol kinase 2.7.1.107 0.650