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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jg7 NAD Antiquitin

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2jg7 NADAntiquitin / 1.218
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 1.067
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.998
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.968
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.957
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.951
3b4w NADAldehyde dehydrogenase family protein / 0.950
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.949
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.930
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.930
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.916
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.916
4pz2 NADAldehyde dehydrogenase 2-6 / 0.916
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.911
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.908
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.905
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.902
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.885
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.877
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.872
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.869
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.867
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.865
4i8p NADAminoaldehyde dehydrogenase 1 / 0.864
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.859
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.856
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.855
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.846
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.844
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.844
4i8q NADPutative betaine aldehyde dehyrogenase / 0.823
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.818
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.813
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.813
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.798
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.796
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.783
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.771
4i3w NADAldehyde dehydrogenase (NAD+) / 0.763
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.756
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.754
4i3v NADAldehyde dehydrogenase (NAD+) / 0.753
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.752
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.747
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.744
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.743
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.742
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.731
4c3s NADAldehyde Dehydrogenase / 0.726
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.722
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.719
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.702
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.696
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.695
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.692
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.692
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.691
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.691
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.690
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
4pt0 NADAldehyde dehydrogenase / 0.685
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.684
3haz NADBifunctional protein PutA / 0.680
4pxl NADAldehyde dehydrogenase3 / 0.679
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.676
4f3x NADPutative aldehyde dehydrogenase / 0.674
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.669
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.665
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.663
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.660
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.658
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.657
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.656
4h73 NDPAldehyde dehydrogenase / 0.656
4wec NADShort chain dehydrogenase / 0.655
1bi9 NADRetinal dehydrogenase 2 / 0.652
4nmj NAPAldehyde dehydrogenase / 0.650