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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ijm ATP Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.899
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.749
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.741
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.738
4c3r ACPAurora kinase A 2.7.11.1 0.723
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.713
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.701
2pup ADPMethylthioribose kinase 2.7.1.100 0.701
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
2olc ADPMethylthioribose kinase 2.7.1.100 0.698
2wqe ADPAurora kinase A 2.7.11.1 0.696
2pun ACPMethylthioribose kinase 2.7.1.100 0.690
2pul ACPMethylthioribose kinase 2.7.1.100 0.689
3b2t M33Fibroblast growth factor receptor 2 / 0.689
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.689
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.689
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.688
1i44 ACPInsulin receptor 2.7.10.1 0.686
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.684
2pui ADPMethylthioribose kinase 2.7.1.100 0.684
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.682
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.682
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.681
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.680
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.679
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.679
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.678
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.678
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.678
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.678
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.678
4o1p ANPRibonuclease L / 0.678
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.677
5d4v YGPUncharacterized protein MJ0489 / 0.677
1u54 ACPActivated CDC42 kinase 1 / 0.675
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.675
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.675
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.672
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.672
3a8w ATPProtein kinase C iota type 2.7.11.13 0.672
4dt8 ADNAPH(2'')-Id / 0.672
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.672
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.672
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.670
3p23 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.670
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.668
3q5i ANPProtein kinase, putative / 0.668
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.668
3orl AGSSerine/threonine protein kinase / 0.666
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.666
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.666
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
4fkl CK2Cyclin-dependent kinase 2 2.7.11.22 0.664
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.663
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.662
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.662
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.662
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.661
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.660
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.660
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.660
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.659
3ork AGSSerine/threonine protein kinase / 0.659
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.659
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.658
4k2r ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.658
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.658
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.657
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.657
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.657
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
5l8j ADPAurora kinase A 2.7.11.1 0.657
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.656
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.656
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.656
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4xlv ACPInsulin receptor 2.7.10.1 0.656
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.655
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.654
3orp AGSSerine/threonine protein kinase / 0.654
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.654
5l8l ADPAurora kinase A 2.7.11.1 0.654
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.653
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.653
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.653
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.651
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.651
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4j98 ACPFibroblast growth factor receptor 2 / 0.651
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.650
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.650