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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ie0 ZID Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.208
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.123
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.101
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.988
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.971
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.970
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.957
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.941
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.910
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.908
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.898
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.879
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.879
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.874
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.872
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.852
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.849
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.845
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.844
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.843
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.843
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.842
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.819
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.812
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.810
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.784
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.780
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.771
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.764
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.761
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.759
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.756
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.753
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.750
2yut NAPPutative short-chain oxidoreductase / 0.745
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.743
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.742
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.741
4bmv NAPShort-chain dehydrogenase / 0.737
3s55 NADPutative short-chain dehydrogenase/reductase / 0.735
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.734
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.732
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.732
4b79 NADProbable short-chain dehydrogenase / 0.730
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.728
3r3s NADPutative oxidoreductase / 0.728
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.722
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.721
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.717
3p19 NDPPutative blue fluorescent protein / 0.716
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.715
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.715
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.713
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.713
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.709
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.708
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.707
3wds NADNADH-dependent quinuclidinone reductase / 0.706
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.705
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.702
2bd0 NAPSepiapterin reductase / 0.699
2dte NAIGlucose 1-dehydrogenase related protein / 0.698
3ak4 NADNADH-dependent quinuclidinone reductase / 0.698
2jah NDPClavaldehyde dehydrogenase / 0.697
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.697
1x7h NDPPutative ketoacyl reductase 1.3.1 0.696
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.696
1w4z NAPPutative ketoacyl reductase 1.3.1 0.695
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.695
1ipe NDPTropinone reductase 2 1.1.1.236 0.693
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.693
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.691
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.690
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.690
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.689
3tsc NADUncharacterized protein / 0.688
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.688
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.688
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.688
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.686
3d3w NAPL-xylulose reductase 1.1.1.10 0.686
1oaa NAPSepiapterin reductase 1.1.1.153 0.685
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.685
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.684
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.683
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.682
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.681
3sju NDPKeto reductase / 0.680
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.679
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.679
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.678
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.677
2wsb NADGalactitol dehydrogenase / 0.677
3qrw NDPPutative ketoacyl reductase 1.3.1 0.677
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.677
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.675
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.675
5jla NADPutative short-chain dehydrogenase/reductase / 0.675
3ai2 NDPNADPH-sorbose reductase / 0.673
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.673
4wec NADShort chain dehydrogenase / 0.673
4yai NAIC alpha-dehydrogenase / 0.673
1xkq NDPUncharacterized protein / 0.672
5d2e NAPMlnE / 0.672
3geg NADShort-chain dehydrogenase/reductase SDR / 0.671
3o26 NDPSalutaridine reductase / 0.670
5jyd NADShort chain dehydrogenase / 0.670
4clo NAPPteridine reductase / 0.669
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.669
1pr9 NAPL-xylulose reductase 1.1.1.10 0.668
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.668
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.667
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.666
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.666
3sx2 NADUncharacterized protein / 0.666
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.666
3ai3 NDPNADPH-sorbose reductase / 0.665
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.664
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.664
2yy7 NADL-threonine dehydrogenase / 0.664
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.664
1sny NAPLD36273p / 0.663
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.663
4yag NAIC alpha-dehydrogenase / 0.663
1ae1 NAPTropinone reductase 1 / 0.661
4dbz NDPPutative ketoacyl reductase 1.3.1 0.661
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.659
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.659
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.659
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.658
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.658
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.656
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.656
4j7u NAPSepiapterin reductase 1.1.1.153 0.656
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.655
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.655
1x7g NAPPutative ketoacyl reductase 1.3.1 0.654
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.654
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.654
3h4v NAPPteridine reductase 1 1.5.1.33 0.653
3k31 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.653
4hxy NDPPlm1 / 0.653
4hwk NAPSepiapterin reductase 1.1.1.153 0.652
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.652
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.651
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.650
1qyv NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.650
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.650