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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fze APR Alcohol dehydrogenase class-3 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.931
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.815
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.813
3uko NADAlcohol dehydrogenase class-3 / 0.796
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.776
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.774
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.768
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.766
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.764
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.764
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.763
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.763
4l0q NADAlcohol dehydrogenase class-3 / 0.759
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.756
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.754
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.753
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.747
4jji NADAlcohol dehydrogenase class-3 / 0.746
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.744
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.743
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.738
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.736
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.736
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.734
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.733
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.731
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.730
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.727
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.721
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.721
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.720
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.717
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.714
4gl4 NAIAlcohol dehydrogenase class-3 / 0.714
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.712
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.710
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.705
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.705
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.703
4k28 NADShikimate dehydrogenase family protein / 0.703
3x2e NAIAdenosylhomocysteinase / 0.702
2x0i NAIMalate dehydrogenase / 0.700
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.699
3x2f NAIAdenosylhomocysteinase / 0.699
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.696
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.696
1f8f NADBenzyl alcohol dehydrogenase / 0.694
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.690
4rqu NADAlcohol dehydrogenase class-P / 0.688
3jv7 NADSecondary alcohol dehydrogenase / 0.687
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.687
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.681
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.680
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.679
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.679
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.678
3ggo NAIPrephenate dehydrogenase / 0.677
1bw9 NADPhenylalanine dehydrogenase / 0.676
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.676
3wle NAD(R)-specific carbonyl reductase / 0.676
1q7g NHOHomoserine dehydrogenase 1.1.1.3 0.675
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.671
2wsb NADGalactitol dehydrogenase / 0.671
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.670
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.670
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.669
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.666
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.666
1c1d NAIPhenylalanine dehydrogenase / 0.665
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.665
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.664
4j4b NAIUncharacterized protein / 0.664
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.663
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.662
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.660
1uxj NADMalate dehydrogenase / 0.660
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.658
2dfv NADL-threonine 3-dehydrogenase / 0.658
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.658
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.658
4cpd NADAlcohol dehydrogenase / 0.657
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.655
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.655
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.654
3ec7 NADInositol 2-dehydrogenase / 0.654
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.653
3d64 NADAdenosylhomocysteinase / 0.653
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.652
4xq9 NADHomospermidine synthase 2.5.1.44 0.652
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.651
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650