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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2eit NAD 1-pyrroline-5-carboxylate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 1.246
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 1.147
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 1.147
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.129
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 1.112
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 1.112
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.107
4pz2 NADAldehyde dehydrogenase 2-6 / 0.991
4i8p NADAminoaldehyde dehydrogenase 1 / 0.938
4i8q NADPutative betaine aldehyde dehyrogenase / 0.933
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.919
3b4w NADAldehyde dehydrogenase family protein / 0.917
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.910
2jg7 NADAntiquitin / 0.908
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.897
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.894
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.892
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.889
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.877
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.865
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.863
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.846
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.844
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.842
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.829
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.811
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.808
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.804
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.802
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.800
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.800
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.782
3haz NADBifunctional protein PutA / 0.775
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.774
4i9b NADPutative betaine aldehyde dehyrogenase / 0.764
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.761
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.759
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.752
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.748
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.741
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.740
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.737
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.737
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.733
4f3x NADPutative aldehyde dehydrogenase / 0.730
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.729
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.729
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.725
4i3w NADAldehyde dehydrogenase (NAD+) / 0.722
4h73 NDPAldehyde dehydrogenase / 0.719
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.708
4nmj NAPAldehyde dehydrogenase / 0.704
4c3s NADAldehyde Dehydrogenase / 0.702
4i3v NADAldehyde dehydrogenase (NAD+) / 0.699
4nmk NAPAldehyde dehydrogenase / 0.697
1bi9 NADRetinal dehydrogenase 2 / 0.694
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.692
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.686
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.679
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.677
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.671
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.666
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.664
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.662
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.655
4pt0 NADAldehyde dehydrogenase / 0.654
5eyu NADBetaine-aldehyde dehydrogenase / 0.650