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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2eii NAD 1-pyrroline-5-carboxylate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 1.314
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 1.258
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.234
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 1.222
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 1.192
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.181
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 1.147
4pz2 NADAldehyde dehydrogenase 2-6 / 1.052
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 1.021
4i8q NADPutative betaine aldehyde dehyrogenase / 0.991
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.987
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.977
3b4w NADAldehyde dehydrogenase family protein / 0.964
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.952
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.948
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.943
4i8p NADAminoaldehyde dehydrogenase 1 / 0.938
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.931
2jg7 NADAntiquitin / 0.916
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.908
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.904
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.889
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.874
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.866
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.855
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.851
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.847
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.846
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.837
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.836
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.833
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.828
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.827
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.824
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.805
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.803
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.801
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.798
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.794
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.794
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.793
3haz NADBifunctional protein PutA / 0.790
4i3v NADAldehyde dehydrogenase (NAD+) / 0.781
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.771
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.770
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.761
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.758
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.754
4nmj NAPAldehyde dehydrogenase / 0.754
4nmk NAPAldehyde dehydrogenase / 0.747
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.744
4i3w NADAldehyde dehydrogenase (NAD+) / 0.743
4h73 NDPAldehyde dehydrogenase / 0.741
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.733
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.717
4c3s NADAldehyde Dehydrogenase / 0.715
4f3x NADPutative aldehyde dehydrogenase / 0.713
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.708
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.708
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.706
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.700
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.698
1bi9 NADRetinal dehydrogenase 2 / 0.697
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.695
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.692
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.692
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.690
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.680
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.680
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.678
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.661
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.659
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.658
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.651