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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2eer NAD NAD-dependent alcohol dehydrogenase 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 1.286
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 1.109
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.994
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.966
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.925
3two NDPMannitol dehydrogenase / 0.912
4c4o NADSADH / 0.909
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.909
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.903
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.894
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.894
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.893
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.881
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.879
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.879
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.878
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.875
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.872
3wle NAD(R)-specific carbonyl reductase / 0.867
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.866
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.866
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.865
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.862
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.860
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.856
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.855
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.852
1yqd NAPSinapyl alcohol dehydrogenase / 0.851
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.846
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.844
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.842
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.840
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.832
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.832
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.829
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.827
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.817
3jv7 NADSecondary alcohol dehydrogenase / 0.815
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.807
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.804
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.801
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.800
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.791
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.786
2xaa NADSecondary alcohol dehydrogenase / 0.784
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.775
4jk3 NADUncharacterized protein / 0.773
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.763
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.762
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.760
1pzh NADLactate dehydrogenase / 0.760
1uxj NADMalate dehydrogenase / 0.760
4oaq NDPR-specific carbonyl reductase / 0.759
4j43 NADUncharacterized protein / 0.753
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.743
1llu NADAlcohol dehydrogenase / 0.742
4j49 NADUncharacterized protein / 0.740
1ib6 NADMalate dehydrogenase / 0.738
1yqx NAPSinapyl alcohol dehydrogenase / 0.737
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.735
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.735
1sow NADL-lactate dehydrogenase 1.1.1.27 0.729
4rqu NADAlcohol dehydrogenase class-P / 0.729
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.728
4b7x NAPProbable oxidoreductase / 0.727
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.725
4i1i NADMalate dehydrogenase / 0.724
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.723
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.723
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.722
1o6z NADMalate dehydrogenase / 0.721
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.721
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.714
1u7h NADPutative ornithine cyclodeaminase / 0.709
1gv0 NADMalate dehydrogenase / 0.708
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.708
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.707
2x0i NAIMalate dehydrogenase / 0.707
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.705
1i3l NADUDP-glucose 4-epimerase / 0.700
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.700
1pzg A3DLactate dehydrogenase / 0.700
1xcb NADRedox-sensing transcriptional repressor Rex / 0.700
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.699
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.698
4hnh NAPNAD-dependent epimerase/dehydratase / 0.697
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.695
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.695
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.694
1uxk NADMalate dehydrogenase / 0.694
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.694
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.694
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.694
1f8f NADBenzyl alcohol dehydrogenase / 0.693
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.692
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.692
1ie3 NADMalate dehydrogenase / 0.691
5a1t NAIL-lactate dehydrogenase / 0.691
1emd NADMalate dehydrogenase / 0.689
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.683
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.682
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.680
1pzf A3DLactate dehydrogenase / 0.679
4j49 NAIUncharacterized protein / 0.674
2voj NADAlanine dehydrogenase 1.4.1.1 0.673
2x0r NADMalate dehydrogenase / 0.672
3wsw NADL-lactate dehydrogenase / 0.670
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.670
3ggg NADPrephenate dehydrogenase / 0.669
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.668
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.666
3sx2 NADUncharacterized protein / 0.666
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.666
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.664
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.663
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.663
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.662
1wze NADMalate dehydrogenase / 0.661
1wzi NDPMalate dehydrogenase / 0.660
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.660
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.659
3kb6 NADD-lactate dehydrogenase / 0.659
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.658
2j3i NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.658
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.657
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.657
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.657
3tqh NDPQuinone oxidoreductase / 0.657
1b8v NADMalate dehydrogenase / 0.656
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.656
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.656
4plp NADHomospermidine synthase 2.5.1.44 0.656
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.653
3ggp NADPrephenate dehydrogenase / 0.653
4kug NAD3-hydroxybutyryl-CoA dehydrogenase / 0.653
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.652
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.652
2dbz NAPGlyoxylate reductase 1.1.1.26 0.651
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.650
4ros APRMalate dehydrogenase / 0.650