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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2acx ANP G protein-coupled receptor kinase 6 2.7.11.16

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.901
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.718
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.704
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.699
3q5i ANPProtein kinase, putative / 0.699
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.696
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.694
1u54 ACPActivated CDC42 kinase 1 / 0.691
3t8o ATPRhodopsin kinase / 0.690
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.689
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.689
2py3 ACPFibroblast growth factor receptor 2 / 0.688
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.687
3a8w ATPProtein kinase C iota type 2.7.11.13 0.684
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.683
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.682
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.681
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.678
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.678
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.677
2pun ACPMethylthioribose kinase 2.7.1.100 0.676
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.674
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.673
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.673
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.671
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.670
3bht MFRCyclin-dependent kinase 2 2.7.11.22 0.670
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.670
2uw0 GVKcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.668
5ckw ANPUncharacterized protein / 0.668
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.666
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.664
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.664
4xlv ACPInsulin receptor 2.7.10.1 0.664
2pz5 ACPFibroblast growth factor receptor 2 / 0.663
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.662
4ix5 ANPUncharacterized protein / 0.662
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.662
2pul ACPMethylthioribose kinase 2.7.1.100 0.660
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.660
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.659
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.659
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.658
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.658
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.658
3c4z ADPRhodopsin kinase / 0.658
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.658
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4bn1 ADPAurora kinase A 2.7.11.1 0.657
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.656
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.656
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.656
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.655
4b8l A0PAurora kinase B-A 2.7.11.1 0.655
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.655
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.654
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.654
2dwb ANPAurora kinase A 2.7.11.1 0.653
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
1oi9 N20Cyclin-dependent kinase 2 2.7.11.22 0.652
3cly ACPFibroblast growth factor receptor 2 / 0.652
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.652
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1wbp ADPSRSF protein kinase 1 2.7.11.1 0.651
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.651
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.651
4bix ADPSensor histidine kinase CpxA / 0.651
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.651
5dr2 ATPAurora kinase A 2.7.11.1 0.651
2uvy GVIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.650