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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zxm ANP DNA topoisomerase 2-alpha 5.99.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 1.234
1pvg ANPDNA topoisomerase 2 5.99.1.3 1.058
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.921
4wud ANPDNA gyrase subunit B / 0.860
1zxn ADPDNA topoisomerase 2-alpha 5.99.1.3 0.829
4wuc ANPDNA gyrase subunit B / 0.816
4r1f ADPDNA topoisomerase 2-alpha 5.99.1.3 0.802
3zkb ANPDNA gyrase subunit B / 0.771
4ivg ANPTNF receptor-associated protein 1 / 0.762
1nhh ANPDNA mismatch repair protein MutL / 0.761
4ipe ANPTNF receptor-associated protein 1 / 0.757
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.728
4xc0 ACPHeat shock cognate 90 kDa protein / 0.708
3t1k ANPHeat shock protein HSP 90-alpha / 0.704
3zkd ANPDNA gyrase subunit B / 0.704
2yef ANPHeat shock protein HSP 90-alpha / 0.702
3t0z ATPHeat shock protein HSP 90-alpha / 0.694
4prx ADPDNA gyrase subunit B / 0.687
4gqt ADPHeat shock protein 90 / 0.683
3rep ATPIntegrin-linked protein kinase 2.7.11.1 0.676
1byq ADPHeat shock protein HSP 90-alpha / 0.675
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.673
2bu8 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.667
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.665
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.662
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.662
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.661
3t2s AGSHeat shock protein HSP 90-alpha / 0.661
3t10 ACPHeat shock protein HSP 90-alpha / 0.659
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.658
2x60 GTPMannose-1-phosphate guanylyltransferase / 0.658
2xcm ADPCytosolic heat shock protein 90 / 0.657
2xk2 ADPHeat shock protein HSP 90-alpha / 0.655
1til ATPAnti-sigma F factor / 0.651
5i4n ATPTyrosine-protein kinase JAK2 / 0.651
1mez GDPAdenylosuccinate synthetase isozyme 1 / 0.650
4xcj ADPHeat shock cognate 90 kDa protein / 0.650
4xcl AGSHeat shock cognate 90 kDa protein / 0.650