Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tqp ATP RIO-type serine/threonine-protein kinase Rio2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.923
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.876
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.822
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.780
2pui ADPMethylthioribose kinase 2.7.1.100 0.757
2olc ADPMethylthioribose kinase 2.7.1.100 0.744
2pun ACPMethylthioribose kinase 2.7.1.100 0.743
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.736
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.731
2pul ACPMethylthioribose kinase 2.7.1.100 0.727
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.727
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.717
5dt4 ATPAurora kinase A 2.7.11.1 0.716
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.715
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.714
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.710
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.709
5dos ATPAurora kinase A 2.7.11.1 0.706
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.705
3t8o ATPRhodopsin kinase / 0.704
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.703
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.703
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.703
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.702
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.702
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.700
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.699
4q5h ANPProtein kinase OspG 2.7 0.697
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.695
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.694
4c3r ACPAurora kinase A 2.7.11.1 0.694
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.693
4ceg ADPAurora kinase A 2.7.11.1 0.692
4gyi ADPUncharacterized protein / 0.691
1ol6 ATPAurora kinase A 2.7.11.1 0.690
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.690
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.690
4ysj ADPCalmodulin-like domain protein kinase / 0.690
4o4e ATPKinase / 0.689
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.687
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.683
3wnz ADPAlanine--anticapsin ligase / 0.683
3ori AGSSerine/threonine protein kinase / 0.682
3c50 ADPRhodopsin kinase / 0.680
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.680
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.678
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.678
1u54 ACPActivated CDC42 kinase 1 / 0.677
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.677
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.675
5l8k ADPAurora kinase A 2.7.11.1 0.675
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.674
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.674
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.674
5dnr ATPAurora kinase A 2.7.11.1 0.674
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.673
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.672
2pup ADPMethylthioribose kinase 2.7.1.100 0.672
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.672
4c3p ACPAurora kinase A 2.7.11.1 0.671
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
3c4w ATPRhodopsin kinase / 0.669
5drd ATPAurora kinase A 2.7.11.1 0.669
4xlv ACPInsulin receptor 2.7.10.1 0.668
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.667
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
5l8l ADPAurora kinase A 2.7.11.1 0.667
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.666
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.666
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.666
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.666
2p0a ANPSynapsin-3 / 0.665
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.665
4qny ANPMitogen activated protein kinase, putative / 0.665
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.664
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.663
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.663
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.662
2pyw ADPMethylthioribose kinase 2.7.1.100 0.662
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.662
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.662
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.661
3wo1 ADPAlanine--anticapsin ligase / 0.661
4ffm ADPUncharacterized protein / 0.661
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.660
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.660
3q5i ANPProtein kinase, putative / 0.660
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.660
4o4d ATPKinase / 0.660
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.659
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.658
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.658
4ffl ADPUncharacterized protein / 0.658
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.658
1px2 ATPSynapsin-1 / 0.657
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.657
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.657
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.657
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.656
2hgs ADPGlutathione synthetase 6.3.2.3 0.656
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.656
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.655
4hne ADPPhosphatidylinositol 4-kinase type 2-alpha / 0.655
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.653
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.653
3ibq ATPPyridoxal kinase / 0.653
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.652
4utd ACPAurora kinase A 2.7.11.1 0.652
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.651
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.651
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.650
3g8d ADPBiotin carboxylase 6.3.4.14 0.650