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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o02 NAD Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.187
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.103
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.094
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.091
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.090
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.076
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 1.021
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 1.020
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.956
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.949
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.943
4pt0 NADAldehyde dehydrogenase / 0.925
4pxl NADAldehyde dehydrogenase3 / 0.871
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.864
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.856
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.852
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.831
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.822
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.795
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.789
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.789
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.787
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.786
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.781
4pt3 NDPAldehyde dehydrogenase / 0.773
4i8p NADAminoaldehyde dehydrogenase 1 / 0.770
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.755
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.751
3b4w NADAldehyde dehydrogenase family protein / 0.748
1bi9 NADRetinal dehydrogenase 2 / 0.746
3iwj NADAminoaldehyde dehydrogenase / 0.743
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.741
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.738
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.735
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.735
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.733
4i8q NADPutative betaine aldehyde dehyrogenase / 0.733
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.731
4i9b NADPutative betaine aldehyde dehyrogenase / 0.730
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.725
4f3x NADPutative aldehyde dehydrogenase / 0.725
4i3w NADAldehyde dehydrogenase (NAD+) / 0.725
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.724
4i3v NADAldehyde dehydrogenase (NAD+) / 0.724
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.710
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.706
5ez4 NADBetaine-aldehyde dehydrogenase / 0.705
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.704
5eyu NADBetaine-aldehyde dehydrogenase / 0.703
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.701
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.700
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.691
4h73 NDPAldehyde dehydrogenase / 0.690
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.688
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.686
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.683
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.682
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.679
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.679
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.675
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.670
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.667
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.667
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.667
5dib NADBetaine-aldehyde dehydrogenase / 0.667
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.666
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.665
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.660
3haz NADBifunctional protein PutA / 0.656
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.656
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.652