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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1llu NAD Alcohol dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1llu NADAlcohol dehydrogenase / 1.275
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.833
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.806
4oaq NDPR-specific carbonyl reductase / 0.781
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.776
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.775
1yqd NAPSinapyl alcohol dehydrogenase / 0.769
1yqx NAPSinapyl alcohol dehydrogenase / 0.758
3two NDPMannitol dehydrogenase / 0.757
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.756
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.742
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.740
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.737
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.737
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.734
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.734
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.734
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.734
4c4o NADSADH / 0.732
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.731
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.729
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.728
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.727
3wle NAD(R)-specific carbonyl reductase / 0.724
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.721
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.720
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.719
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.719
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.717
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.716
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.714
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.714
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.710
1u7h NADPutative ornithine cyclodeaminase / 0.707
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.704
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.703
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.699
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.699
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.698
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.697
1gv0 NADMalate dehydrogenase / 0.696
1uxk NADMalate dehydrogenase / 0.696
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.695
3jv7 NADSecondary alcohol dehydrogenase / 0.692
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.690
1uxj NADMalate dehydrogenase / 0.687
1x7d NADPutative ornithine cyclodeaminase / 0.685
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.684
2x0i NAIMalate dehydrogenase / 0.684
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.682
2xaa NADSecondary alcohol dehydrogenase / 0.679
3uko NADAlcohol dehydrogenase class-3 / 0.679
4j43 NADUncharacterized protein / 0.679
1pzh NADLactate dehydrogenase / 0.676
3nx4 NAPPutative oxidoreductase / 0.674
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.673
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.672
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.672
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.671
4xrg NADHomospermidine synthase 2.5.1.44 0.670
1bdm NAXMalate dehydrogenase / 0.669
1o6z NADMalate dehydrogenase / 0.669
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.668
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.667
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.666
4l0q NADAlcohol dehydrogenase class-3 / 0.666
2fkn NADUrocanate hydratase 4.2.1.49 0.665
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.664
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.663
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.663
2cda NAPGlucose 1-dehydrogenase / 0.661
4gl4 NAIAlcohol dehydrogenase class-3 / 0.661
4jk3 NADUncharacterized protein / 0.661
3abi NADUncharacterized protein / 0.660
4jji NADAlcohol dehydrogenase class-3 / 0.660
4rqu NADAlcohol dehydrogenase class-P / 0.660
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.659
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.658
1b8u NADMalate dehydrogenase / 0.656
4cpd NADAlcohol dehydrogenase / 0.656
1sow NADL-lactate dehydrogenase 1.1.1.27 0.653
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.653
1omo NADAlanine dehydrogenase / 0.652
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.652
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.651
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.650
2y05 NAPProstaglandin reductase 1 / 0.650
3f3s NADLambda-crystallin homolog / 0.650
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.650