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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jbp ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.978
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.818
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.816
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.813
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.804
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.796
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.781
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.777
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.760
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.754
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.729
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.726
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.721
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.715
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.712
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.711
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.710
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.710
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.709
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.708
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.705
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.705
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.704
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.699
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.698
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.697
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
5dt3 ATPAurora kinase A 2.7.11.1 0.694
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.693
5dos ATPAurora kinase A 2.7.11.1 0.693
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.692
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.691
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.690
2pml ANPUncharacterized protein / 0.690
4ysj ADPCalmodulin-like domain protein kinase / 0.690
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.689
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.688
5ce3 ADPProtein kinase YopO / 0.688
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.686
1pk8 ATPSynapsin-1 / 0.683
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.683
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.683
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
5dr2 ATPAurora kinase A 2.7.11.1 0.680
2vqd AP2Biotin carboxylase 6.3.4.14 0.679
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.677
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.677
5dn3 ATPAurora kinase A 2.7.11.1 0.677
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.676
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.676
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.676
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.674
4dee ADPAurora kinase A 2.7.11.1 0.674
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.674
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.673
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.673
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.673
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.672
5drd ATPAurora kinase A 2.7.11.1 0.672
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.671
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.671
3cly ACPFibroblast growth factor receptor 2 / 0.671
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.670
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.670
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.670
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.670
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.669
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.669
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.669
3a5y KAAElongation factor P--(R)-beta-lysine ligase / 0.668
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.668
2dwb ANPAurora kinase A 2.7.11.1 0.667
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.667
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.666
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.665
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.665
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.665
4o0w ADNAurora kinase A 2.7.11.1 0.665
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.665
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.663
4utd ACPAurora kinase A 2.7.11.1 0.663
2pyw ADPMethylthioribose kinase 2.7.1.100 0.662
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.662
3nie ANPMitogen-activated protein kinase / 0.661
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.661
3t8o ATPRhodopsin kinase / 0.660
3wnz ADPAlanine--anticapsin ligase / 0.660
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.659
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.658
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.658
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.657
4bn1 ADPAurora kinase A 2.7.11.1 0.657
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.656
5dnr ATPAurora kinase A 2.7.11.1 0.656
2dv7 SAHDiphthine synthase / 0.655
2eld SAHDiphthine synthase / 0.655
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.655
3q60 ATPRhoptry protein 5B / 0.655
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.654
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.653
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
1mq4 ADPAurora kinase A 2.7.11.1 0.652
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.652
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.652
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.652
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.651
2e08 SAHDiphthine synthase / 0.651
2egl SAHDiphthine synthase / 0.651
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.651
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.651
4o1p ANPRibonuclease L / 0.651
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.651
2ek4 SAHDiphthine synthase / 0.650
2p9d SAHDiphthine synthase / 0.650
2pb6 SAHDiphthine synthase / 0.650
2pch SAHDiphthine synthase / 0.650
2z6r SAHDiphthine synthase / 0.650
3bu5 ATPInsulin receptor 2.7.10.1 0.650
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.650
4kpu FADElectron transfer flavoprotein alpha/beta-subunit / 0.650