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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dxq FAD NAD(P)H dehydrogenase [quinone] 1 1.6.5.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.192
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.983
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.958
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.958
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.941
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.939
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.939
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.937
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.919
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.918
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.908
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.899
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.896
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.889
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.877
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.869
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.868
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.828
4gi5 FADPutative NAD(P)H dehydrogenase (Quinone) / 0.770
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.757
2h8x FMNXenA / 0.726
3lcm FADPutative oxidoreductase / 0.719
2ohj FMNType A flavoprotein FprA 1 0.717
2z9d FMNFMN-dependent NADH-azoreductase / 0.717
1ycg FMNNitric oxide reductase 1 0.714
3w77 FMNFMN-dependent NADH-azoreductase / 0.703
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.700
4j8p FMNFlavodoxin / 0.700
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.699
4r81 FMNPredicted NADH dehydrogenase / 0.696
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
3p84 FMNPentaerythritol tetranitrate reductase / 0.695
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.694
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.694
2hpv FMNFMN-dependent NADH-azoreductase 1.7 0.693
1z48 FMNNADPH dehydrogenase / 0.692
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.692
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.691
3atz FMNProstaglandin F2a synthase / 0.691
4cw5 FMNDfnA / 0.691
1vyr FMNPentaerythritol tetranitrate reductase / 0.688
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.688
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.688
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.688
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.687
3f03 FMNPentaerythritol tetranitrate reductase / 0.686
3l5l FMNXenobiotic reductase / 0.685
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.684
4utk FNRXenobiotic reductase / 0.684
5jsc FADPutative acyl-CoA dehydrogenase / 0.684
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.683
1h50 FMNPentaerythritol tetranitrate reductase / 0.682
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.682
1ycf FMNNitric oxide reductase 1 0.681
3k4n FADPyranose 2-oxidase / 0.681
3p8j FMNPentaerythritol tetranitrate reductase / 0.681
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.681
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.680
3l67 FMNXenobiotic reductase / 0.680
2fcr FMNFlavodoxin / 0.679
4tmc FMNOld yellow enzyme / 0.678
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.676
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.675
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.674
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.673
3pl8 FADPyranose 2-oxidase / 0.673
4n9q FMNFMN-dependent NADH-azoreductase 1 / 0.673
4yco FMNtRNA-dihydrouridine(16) synthase / 0.673
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.672
3hf3 FMNChromate reductase / 0.672
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.671
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.671
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.670
3b03 VNRIsopentenyl-diphosphate delta-isomerase / 0.670
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
3zho FMNNAD(P)H dehydrogenase (quinone) / 0.670
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.670
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.670
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.669
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.669
4utm FNRXenobiotic reductase / 0.669
3bi5 FADPolyamine oxidase FMS1 / 0.667
4dy4 FMNNAD(P)H dehydrogenase (quinone) / 0.666
1h51 FMNPentaerythritol tetranitrate reductase / 0.665
2r96 FMNNAD(P)H dehydrogenase (quinone) / 0.665
2z6i FMN2-nitropropane dioxygenase / 0.665
3p67 FMNPentaerythritol tetranitrate reductase / 0.665
3p82 FMNPentaerythritol tetranitrate reductase / 0.665
4mih FADPyranose 2-oxidase 1.1.3.10 0.665
1h63 FMNPentaerythritol tetranitrate reductase / 0.663
2pg0 FADAcyl-CoA dehydrogenase / 0.663
4kuk RBFPutative blue-light photoreceptor / 0.663
4opl FDAConserved Archaeal protein / 0.662
4uth FMNXenobiotic reductase / 0.661
3lsh FADPyranose 2-oxidase / 0.660
3n39 FMNProtein NrdI / 0.660
2ign FADPyranose 2-oxidase / 0.659
2j6x FMNLactate oxidase / 0.659
4nev FADTrypanothione reductase / 0.658
4tmb FMNOld yellow enzyme / 0.658
3qvr FADGlucose oxidase 1.1.3.4 0.657
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.657
4oxx FMNCindoxin / 0.657
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.656
4hs4 FMNChromate reductase / 0.656
3gg0 FMNUncharacterized protein / 0.655
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
2g37 FADProline dehydrogenase / 0.654
2z6c FMNPhototropin-1 2.7.11.1 0.654
3k4c FADPyranose 2-oxidase / 0.654
3lsi FADPyranose 2-oxidase / 0.654
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.653
1zx9 FADMercuric reductase 1.16.1.1 0.653
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.653
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
4m5p FMNNADPH dehydrogenase / 0.653
4mok FADPyranose 2-oxidase / 0.653
4yl2 FMNLactate oxidase / 0.653
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.652
1reo FADL-amino-acid oxidase 1.4.3.2 0.652
2gjl FMNNitronate monooxygenase 1.13.12.16 0.652
2iyg FMNAppA, antirepressor of ppsR, sensor of blue light / 0.652
1nb9 RBFRiboflavin kinase 2.7.1.26 0.651
1ofv FMNFlavodoxin / 0.651
2z1q FADAcyl-CoA dehydrogenase / 0.651
3mkh FADNitroalkane oxidase / 0.651
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.650
1hsk FADUDP-N-acetylenolpyruvoylglucosamine reductase / 0.650
1vhn FMNtRNA-dihydrouridine synthase / 0.650
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
4e2b FMNDehydrogenase / 0.650
4j57 FADThioredoxin reductase 2 1.8.1.9 0.650