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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1adc PAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 1.271
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.985
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.939
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.935
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.932
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.926
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.926
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.925
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.924
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.921
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.919
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.914
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.913
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.913
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.910
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.909
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.905
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.900
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.899
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.897
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.895
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.895
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.895
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.895
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.895
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.894
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.882
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.880
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.880
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.866
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.863
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.863
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.855
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.854
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.851
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.849
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.844
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.843
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.841
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.825
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.822
3two NDPMannitol dehydrogenase / 0.818
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.817
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.816
3wle NAD(R)-specific carbonyl reductase / 0.816
4rqu NADAlcohol dehydrogenase class-P / 0.812
1x7d NADPutative ornithine cyclodeaminase / 0.805
4c4o NADSADH / 0.803
1f8f NADBenzyl alcohol dehydrogenase / 0.798
3jv7 NADSecondary alcohol dehydrogenase / 0.793
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.779
1yqx NAPSinapyl alcohol dehydrogenase / 0.763
1u7h NADPutative ornithine cyclodeaminase / 0.761
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.761
4gl4 NAIAlcohol dehydrogenase class-3 / 0.757
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.743
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.740
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.740
4oaq NDPR-specific carbonyl reductase / 0.739
4cpd NADAlcohol dehydrogenase / 0.738
1uxj NADMalate dehydrogenase / 0.736
4jk3 NADUncharacterized protein / 0.736
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.728
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.724
1llu NADAlcohol dehydrogenase / 0.717
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.716
1o6z NADMalate dehydrogenase / 0.713
1uxk NADMalate dehydrogenase / 0.713
2dfv NADL-threonine 3-dehydrogenase / 0.712
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.706
3nx4 NAPPutative oxidoreductase / 0.705
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.703
3ggp NADPrephenate dehydrogenase / 0.702
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.702
4jji NADAlcohol dehydrogenase class-3 / 0.701
1yqd NAPSinapyl alcohol dehydrogenase / 0.699
4j49 NADUncharacterized protein / 0.699
2g5c NADPrephenate dehydrogenase / 0.698
4b7x NAPProbable oxidoreductase / 0.697
1gv0 NADMalate dehydrogenase / 0.692
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.692
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.690
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.688
4ejm NAPPutative zinc-binding dehydrogenase / 0.688
1guy NADMalate dehydrogenase / 0.687
3ggo NAIPrephenate dehydrogenase / 0.687
1q7g NHOHomoserine dehydrogenase 1.1.1.3 0.685
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.685
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.684
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.681
4k28 NADShikimate dehydrogenase family protein / 0.679
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.679
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.677
2ph5 NADHomospermidine synthase / 0.677
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.676
2o4c NADErythronate-4-phosphate dehydrogenase / 0.674
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.674
4i1i NADMalate dehydrogenase / 0.674
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.669
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.668
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.668
4j49 NAIUncharacterized protein / 0.668
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.666
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.665
2a92 NAIL-lactate dehydrogenase / 0.664
1bdm NAXMalate dehydrogenase / 0.663
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.663
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.663
1xq6 NAPUncharacterized protein At5g02240 / 0.662
3kb6 NADD-lactate dehydrogenase / 0.660
3uko NADAlcohol dehydrogenase class-3 / 0.660
4j43 NADUncharacterized protein / 0.660
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.659
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.659
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.659
1sow NADL-lactate dehydrogenase 1.1.1.27 0.657
5a02 NAPGlucose-fructose oxidoreductase / 0.657
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.656
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.655
1pzh NADLactate dehydrogenase / 0.655
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.655
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.655
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.655
2x0i NAIMalate dehydrogenase / 0.653
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.652
1qor NDPQuinone oxidoreductase 1 / 0.651
1xcb NADRedox-sensing transcriptional repressor Rex / 0.651
3oet NADErythronate-4-phosphate dehydrogenase / 0.651
2rir NAPDipicolinate synthase subunit A / 0.650
4xq9 NADHomospermidine synthase 2.5.1.44 0.650