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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
9gssGTXGlutathione S-transferase P2.5.1.18

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
9gssGTXGlutathione S-transferase P2.5.1.181.000
13gsSASGlutathione S-transferase P2.5.1.180.807
17gsGTXGlutathione S-transferase P2.5.1.180.788
2a2sGSNGlutathione S-transferase P2.5.1.180.709
12gs0HHGlutathione S-transferase P2.5.1.180.689
3pgtGBXGlutathione S-transferase P2.5.1.180.639
2glrGTXGlutathione S-transferase P 12.5.1.180.633
3gusN11Glutathione S-transferase P2.5.1.180.631
2j9hGTXGlutathione S-transferase P2.5.1.180.630
2oa7GTXGlutathione S-transferase P 12.5.1.180.627
1pgtGTXGlutathione S-transferase P2.5.1.180.626
2oadGTBGlutathione S-transferase P 12.5.1.180.623
1gtiGTBGlutathione S-transferase P 12.5.1.180.621
3ie3N11Glutathione S-transferase P2.5.1.180.610
1aqxGTDGlutathione S-transferase P2.5.1.180.608
3csjCBLGlutathione S-transferase P2.5.1.180.568
2pgtGPRGlutathione S-transferase P2.5.1.180.566
20gsCBDGlutathione S-transferase P2.5.1.180.562
3o76GTBGlutathione S-transferase P 12.5.1.180.548
1gssLEEGlutathione S-transferase P2.5.1.180.528
1aqv0HGGlutathione S-transferase P2.5.1.180.520
3n9jEAAGlutathione S-transferase P2.5.1.180.514
3dgqEAAGlutathione S-transferase P2.5.1.180.511
2oacGTBGlutathione S-transferase P 12.5.1.180.491
2gstGPSGlutathione S-transferase Mu 12.5.1.180.466
2vqbNAPPutative flavin-containing monooxygenase/0.465
1xddAAYIntegrin alpha-L/0.464
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4bfzZVZPantothenate kinase2.7.1.330.461
3br3ETHTH-type transcriptional regulator QacR/0.460
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.459
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.457
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.457
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3ai3NDPNADPH-sorbose reductase/0.454
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.452
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.451
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.451
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.451
3gstGPRGlutathione S-transferase Mu 12.5.1.180.451
1vi2NADQuinate/shikimate dehydrogenase/0.450
1towCRZFatty acid-binding protein, adipocyte/0.449
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.449
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.449
3n19FNRXenobiotic reductase/0.448
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.446
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.445
2vd0D27Hematopoietic prostaglandin D synthase/0.445
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.444
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3imgBZ2Pantothenate synthetase6.3.2.10.444
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.444
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.443
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.443
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.442
2x3jATPAcsD/0.442
2ylrNAPPhenylacetone monooxygenase1.14.13.920.442
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.441
1s7lCOAAcetyl transferase/0.440
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2fjeFADAdenylylsulfate reductase, subunit A (AprA)/0.440
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.440