sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5cb4 | ACP | Tubulin tyrosine ligase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5cb4 | ACP | Tubulin tyrosine ligase | / | 1.000 | |
| 5ca0 | ACP | Tubulin tyrosine ligase | / | 0.628 | |
| 5c8y | ACP | Tubulin tyrosine ligase | / | 0.623 | |
| 4zol | ACP | Tubulin tyrosine ligase | / | 0.585 | |
| 4zhq | ACP | Tubulin tyrosine ligase | / | 0.528 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.496 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.476 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.470 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.462 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.459 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.458 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.456 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.454 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.452 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.452 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 2iw9 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.450 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.449 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2iw6 | QQ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.445 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.444 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.443 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.442 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.442 | |
| 1r2j | FAD | FkbI | / | 0.441 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.441 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.441 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.440 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 4uux | APR | CinA-like protein | / | 0.440 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.440 |