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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kin1M8Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kin1M8Mitogen-activated protein kinase 14/1.000
3ocgOCGMitogen-activated protein kinase 14/0.565
3mpt1GKMitogen-activated protein kinase 14/0.559
3iphG11Mitogen-activated protein kinase 14/0.547
2rg5279Mitogen-activated protein kinase 14/0.544
3fklFKLMitogen-activated protein kinase 14/0.537
4kip1R9Mitogen-activated protein kinase 14/0.537
4lopSB4Mitogen-activated protein kinase 14/0.535
3fln3FNMitogen-activated protein kinase 14/0.528
3dt1P40Mitogen-activated protein kinase 14/0.527
3hl7I47Mitogen-activated protein kinase 14/0.527
4aa5NQBMitogen-activated protein kinase 14/0.527
4kiq1RAMitogen-activated protein kinase 14/0.525
4aa4QC0Mitogen-activated protein kinase 14/0.523
2balPQAMitogen-activated protein kinase 14/0.520
2rg6287Mitogen-activated protein kinase 14/0.515
3l8xN4DMitogen-activated protein kinase 14/0.515
2qd9LGFMitogen-activated protein kinase 14/0.512
3s4qNK0Mitogen-activated protein kinase 14/0.512
3nww3NWMitogen-activated protein kinase 14/0.504
3fi4FI4Mitogen-activated protein kinase 14/0.502
3fmh533Mitogen-activated protein kinase 14/0.502
1zz2B11Mitogen-activated protein kinase 14/0.495
4eh60ONMitogen-activated protein kinase 14/0.494
3gfeP37Mitogen-activated protein kinase 14/0.493
3flzFLZMitogen-activated protein kinase 14/0.488
4looSB4Mitogen-activated protein kinase 14/0.488
3fmkFMKMitogen-activated protein kinase 14/0.485
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.483
4loqSB4Mitogen-activated protein kinase 14/0.483
3gc9B45Mitogen-activated protein kinase 112.7.11.240.481
3uvqFS8Mitogen-activated protein kinase 14/0.481
2ghlLIBMitogen-activated protein kinase 14/0.479
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.479
2acxANPG protein-coupled receptor kinase 62.7.11.160.478
3flwFLWMitogen-activated protein kinase 14/0.478
3flyFLYMitogen-activated protein kinase 14/0.477
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.475
1yw2PGJMitogen-activated protein kinase 14/0.474
1zyjBI5Mitogen-activated protein kinase 14/0.473
4kl9NDPDihydrofolate reductase1.5.1.30.471
4tuvCPZCytochrome P450 1191.140.468
3uvp048Mitogen-activated protein kinase 14/0.467
4qnaX11Serine/threonine-protein kinase 242.7.11.10.466
2qboCAMCamphor 5-monooxygenase1.14.15.10.464
3hllI45Mitogen-activated protein kinase 14/0.464
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.464
4y95746Tyrosine-protein kinase/0.464
3d7zGK5Mitogen-activated protein kinase 14/0.462
3wrmCAMCamphor 5-monooxygenase1.14.15.10.462
2henADPEphrin type-B receptor 22.7.10.10.461
3bv2P38Mitogen-activated protein kinase 14/0.461
4fob0USALK tyrosine kinase receptor2.7.10.10.461
2izuP01Casein kinase I isoform gamma-32.7.11.10.460
4y8wSTRSteroid 21-hydroxylase/0.460
1bim0QBRenin3.4.23.150.459
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.459
4g2fC07Ephrin type-A receptor 32.7.10.10.459
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.459
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.458
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.458
3ggpNADPrephenate dehydrogenase/0.458
4l4cCAMCamphor 5-monooxygenase1.14.15.10.458
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.457
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.456
1rw8580TGF-beta receptor type-12.7.11.300.455
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.455
4c02TAKActivin receptor type-12.7.11.300.455
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.455
4y93746Tyrosine-protein kinase/0.455
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.454
3nxxNDPDihydrofolate reductase1.5.1.30.453
4gk3L87Ephrin type-A receptor 32.7.10.10.453
3mvl38PMitogen-activated protein kinase 14/0.452
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
1xddAAYIntegrin alpha-L/0.451
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2y6o1N1Ephrin type-A receptor 42.7.10.10.451
3iaeD7KBenzaldehyde lyase/0.451
3l63CAMCamphor 5-monooxygenase1.14.15.10.451
3uyt0CKCasein kinase I isoform delta2.7.11.10.451
2c29NAPDihydroflavonol 4-reductase/0.450
2ev9NAPShikimate dehydrogenase (NADP(+))/0.450
1c2tGARPhosphoribosylglycinamide formyltransferase/0.449
1qvnFRIInterleukin-2/0.449
1rbzKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.449
2a7r5GPGMP reductase 2/0.449
2gs7ANPEpidermal growth factor receptor2.7.10.10.449
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.449
3r83Z14Cyclin-dependent kinase 22.7.11.220.449
1c2tNHSPhosphoribosylglycinamide formyltransferase/0.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1ouk084Mitogen-activated protein kinase 14/0.448
2b7aIZATyrosine-protein kinase JAK2/0.448
3mvm39PMitogen-activated protein kinase 14/0.448
4l4bCAMCamphor 5-monooxygenase1.14.15.10.448
1g1aNADdTDP-glucose 4,6-dehydratase/0.447
1pdhFASp-hydroxybenzoate hydroxylase/0.447
1pjkANPCasein kinase II subunit alpha2.7.11.10.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.447
3qlsNDPDihydrofolate reductase1.5.1.30.447
1a72PADAlcohol dehydrogenase E chain1.1.1.10.446
3cscACOCitrate synthase, mitochondrial2.3.3.10.446
3wrlCAMCamphor 5-monooxygenase1.14.15.10.446
1c1dNAIPhenylalanine dehydrogenase/0.445
2qo9ANPEphrin type-A receptor 32.7.10.10.445
3hvcGG5Mitogen-activated protein kinase 14/0.445
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.445
1bygSTUTyrosine-protein kinase CSK/0.444
1ida0POGag-Pol polyprotein3.4.23.470.444
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.444
2cig1DGDihydrofolate reductase1.5.1.30.444
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.444
3mpaSB2Mitogen-activated protein kinase 14/0.444
4cp4CAMCamphor 5-monooxygenase1.14.15.10.444
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.444
1xny191Propionyl-CoA carboxylase complex B subunit/0.443
2wotZZGTGF-beta receptor type-12.7.11.300.443
3bv3P39Mitogen-activated protein kinase 14/0.443
3cukFADD-amino-acid oxidase1.4.3.30.443
3gubGUBDeath-associated protein kinase 12.7.11.10.443
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.443
3itzP66Mitogen-activated protein kinase 14/0.443
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.443
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.443
3w0hW12Vitamin D3 receptor/0.443
1rbqKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.442
3kf7L9GMitogen-activated protein kinase 14/0.442
4uyf73BBromodomain-containing protein 2/0.442
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1kzjCB3Thymidylate synthase/0.441
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.441
2vx07X7Ephrin type-B receptor 42.7.10.10.441
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
5eccNAPDehydrofolate reductase type I/0.441
1ie3NADMalate dehydrogenase/0.440
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
1rbyGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.440
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.440
2q9fC3SCholesterol 24-hydroxylase/0.440
2zgyGDPPlasmid segregation protein ParM/0.440
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3vjoANPEpidermal growth factor receptor2.7.10.10.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4gk2L66Ephrin type-A receptor 32.7.10.10.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440