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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m64393Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3m64393Aldose reductase1.1.1.211.000
2ikj393Aldose reductase1.1.1.210.801
2dv0ZSTAldose reductase1.1.1.210.737
3lqlLDTAldose reductase1.1.1.210.736
2fz9ZSTAldose reductase1.1.1.210.722
3lboLDTAldose reductase1.1.1.210.704
2hvoZSTAldose reductase1.1.1.210.686
3m4h388Aldose reductase1.1.1.210.684
2hv5ZSTAldose reductase1.1.1.210.667
1z8962PAldose reductase1.1.1.210.660
3lz5LDTAldose reductase1.1.1.210.660
2ikhLITAldose reductase1.1.1.210.659
4gca2X9Aldose reductase1.1.1.210.655
2pdxZSTAldose reductase1.1.1.210.652
2pdmZSTAldose reductase1.1.1.210.648
3ghrLDTAldose reductase1.1.1.210.643
1t41ID5Aldose reductase1.1.1.210.639
2hvnZSTAldose reductase1.1.1.210.636
2fz8ZSTAldose reductase1.1.1.210.626
3ld5LDTAldose reductase1.1.1.210.626
1z3n3NAAldose reductase1.1.1.210.623
2iki388Aldose reductase1.1.1.210.617
3mb9ZSTAldose reductase1.1.1.210.616
3mc5393Aldose reductase1.1.1.210.609
1t40ID5Aldose reductase1.1.1.210.608
3ghsLDTAldose reductase1.1.1.210.607
2pd5ZSTAldose reductase1.1.1.210.603
2pdbZSTAldose reductase1.1.1.210.603
2pdg47DAldose reductase1.1.1.210.601
2pdlTOLAldose reductase1.1.1.210.599
3m0iZSTAldose reductase1.1.1.210.596
2pdc393Aldose reductase1.1.1.210.593
2duxZSTAldose reductase1.1.1.210.585
4yu153NAldose reductase1.1.1.210.585
2pdfZSTAldose reductase1.1.1.210.584
3lenZSTAldose reductase1.1.1.210.581
3t423T4Aldose reductase1.1.1.210.580
1pwlBFIAldose reductase1.1.1.210.579
2pdh47DAldose reductase1.1.1.210.577
2pzn393Aldose reductase1.1.1.210.576
2pdu393Aldose reductase1.1.1.210.573
3ghtLDTAldose reductase1.1.1.210.567
1ieiZESAldose reductase1.1.1.210.564
3ghuLDTAldose reductase1.1.1.210.561
2pdn47DAldose reductase1.1.1.210.560
2pdp393Aldose reductase1.1.1.210.557
2duzZSTAldose reductase1.1.1.210.556
2i16LDTAldose reductase1.1.1.210.552
2fzdTOLAldose reductase1.1.1.210.551
2i17LDTAldose reductase1.1.1.210.548
1el3I84Aldose reductase1.1.1.210.540
1frbZSTAldose reductase-related protein 2/0.539
2pdj393Aldose reductase1.1.1.210.537
1us0LDTAldose reductase1.1.1.210.526
2fzbTOLAldose reductase1.1.1.210.520
3g5eQ74Aldose reductase1.1.1.210.519
2pdq47DAldose reductase1.1.1.210.516
1ah3TOLAldose reductase1.1.1.210.508
2pdwFIDAldose reductase1.1.1.210.492
2iqdLPAAldose reductase1.1.1.210.489
5liu388Aldo-keto reductase family 1 member B101.1.10.478
2qxwLDTAldose reductase1.1.1.210.476
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.472
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
2f2kTGGAldose reductase1.1.1.210.469
1u65CP0Acetylcholinesterase3.1.1.70.465
2f3815MAldo-keto reductase family 1 member C3/0.464
2pdyFIDAldose reductase1.1.1.210.464
2agtFIDAldose reductase1.1.1.210.463
4i9i1DYTankyrase-12.4.2.300.462
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.458
2xupTZ5Acetylcholinesterase3.1.1.70.455
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.455
3mjrAC2Deoxycytidine kinase2.7.1.740.455
4k4eK4ETankyrase-12.4.2.300.455
4hyf1AKTankyrase-22.4.2.300.454
1zgcA2EAcetylcholinesterase3.1.1.70.453
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3zv7NHGAcetylcholinesterase3.1.1.70.453
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2oazI96Methionine aminopeptidase 2/0.452
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.452
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.451
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.451
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
4xwtU5PRibonuclease J/0.450
3pn1IVHDNA ligase/0.449
4dbw511Aldo-keto reductase family 1 member C3/0.449
4pnmNU1Tankyrase-22.4.2.300.449
1q83TZ5Acetylcholinesterase3.1.1.70.448
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.448
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2cekN8TAcetylcholinesterase3.1.1.70.447
4li61XOTankyrase-12.4.2.300.447
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
4wevSUZAldo-keto reductase family 1 member B101.1.10.446
3f3y4OABile salt sulfotransferase2.8.2.140.445
3p9tTCLRepressor/0.445
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1w4lGL8Acetylcholinesterase3.1.1.70.443
2w6cBM4Acetylcholinesterase3.1.1.70.443
4zasTYDCalS13/0.443
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.442
2bjsACVIsopenicillin N synthase1.21.3.10.442
3jq8DX3Pteridine reductase, putative/0.442
3zkuHCVIsopenicillin N synthase1.21.3.10.442
1vkgCRIHistone deacetylase 83.5.1.980.441
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3gf4UPGUDP-galactopyranose mutase5.4.99.90.441
4mt92D6Tankyrase-12.4.2.300.441
4psbGA3Cytokinin-specific binding protein/0.441
4u95MIYMultidrug efflux pump subunit AcrB/0.441
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.440
4msk2C8Tankyrase-12.4.2.300.440