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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.137

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1371.000
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.526
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.522
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.512
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.503
4l2yXXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.499
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.498
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.495
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.493
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.490
4izy1J2Mitogen-activated protein kinase 82.7.11.240.490
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.487
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.482
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.481
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.479
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.478
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.478
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.477
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.476
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.471
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
3gc9B45Mitogen-activated protein kinase 112.7.11.240.469
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
4hyu1BKMitogen-activated protein kinase 82.7.11.240.466
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.464
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.460
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.460
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.456
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.455
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.454
5bp9SAHPutative methyltransferase protein/0.453
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.451
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.450
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.450
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.449
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2fpcSCGStrictosidine synthase4.3.3.20.448
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
4j6i1JVPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
3r6pA8SAbscisic acid receptor PYL10/0.446
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
5ap57RODual specificity protein kinase TTK2.7.12.10.446
4cp4CAMCamphor 5-monooxygenase1.14.15.10.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2bujSTUSerine/threonine-protein kinase 16/0.443
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.443
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.443
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.442
3lfcZ86Mitogen-activated protein kinase 14/0.442
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3t8oATPRhodopsin kinase/0.442
4jqh1MFAlr2278 protein/0.442
3cppCAMCamphor 5-monooxygenase1.14.15.10.441
3havATPAminoglycoside phosphotransferase/0.441
3njoP2MAbscisic acid receptor PYR1/0.441
4aguD15Cyclin-dependent kinase-like 1/0.441
4kkyCAMCamphor 5-monooxygenase1.14.15.10.441
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.441
5k2aZMAAdenosine receptor A2a/0.441
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4xwtU5PRibonuclease J/0.440