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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lenZSTAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3lenZSTAldose reductase1.1.1.211.000
3mb9ZSTAldose reductase1.1.1.210.695
2pd5ZSTAldose reductase1.1.1.210.639
2pdbZSTAldose reductase1.1.1.210.635
3mc5393Aldose reductase1.1.1.210.629
2pdp393Aldose reductase1.1.1.210.621
3m0iZSTAldose reductase1.1.1.210.619
2hvoZSTAldose reductase1.1.1.210.615
4gca2X9Aldose reductase1.1.1.210.615
2fz9ZSTAldose reductase1.1.1.210.606
2hv5ZSTAldose reductase1.1.1.210.598
2duzZSTAldose reductase1.1.1.210.596
3t423T4Aldose reductase1.1.1.210.596
1z3n3NAAldose reductase1.1.1.210.595
2fz8ZSTAldose reductase1.1.1.210.591
2dv0ZSTAldose reductase1.1.1.210.590
1t40ID5Aldose reductase1.1.1.210.587
2pdxZSTAldose reductase1.1.1.210.587
2duxZSTAldose reductase1.1.1.210.586
2iki388Aldose reductase1.1.1.210.583
3lboLDTAldose reductase1.1.1.210.582
1t41ID5Aldose reductase1.1.1.210.581
2pdc393Aldose reductase1.1.1.210.581
3m64393Aldose reductase1.1.1.210.577
2qxwLDTAldose reductase1.1.1.210.576
1frbZSTAldose reductase-related protein 2/0.575
4yu153NAldose reductase1.1.1.210.575
1z8962PAldose reductase1.1.1.210.574
2pdh47DAldose reductase1.1.1.210.571
2ikj393Aldose reductase1.1.1.210.570
3lqlLDTAldose reductase1.1.1.210.566
3m4h388Aldose reductase1.1.1.210.565
2i16LDTAldose reductase1.1.1.210.562
3g5eQ74Aldose reductase1.1.1.210.562
2pdg47DAldose reductase1.1.1.210.560
2pzn393Aldose reductase1.1.1.210.560
3ghsLDTAldose reductase1.1.1.210.559
1us0LDTAldose reductase1.1.1.210.557
2pdfZSTAldose reductase1.1.1.210.556
3ld5LDTAldose reductase1.1.1.210.556
3ghuLDTAldose reductase1.1.1.210.555
2ikhLITAldose reductase1.1.1.210.552
3ghtLDTAldose reductase1.1.1.210.552
2pdlTOLAldose reductase1.1.1.210.551
1pwlBFIAldose reductase1.1.1.210.550
3lz5LDTAldose reductase1.1.1.210.549
2pdn47DAldose reductase1.1.1.210.548
2i17LDTAldose reductase1.1.1.210.542
3ghrLDTAldose reductase1.1.1.210.541
1ieiZESAldose reductase1.1.1.210.539
2pevNDPAldose reductase1.1.1.210.518
2fzdTOLAldose reductase1.1.1.210.517
1ah3TOLAldose reductase1.1.1.210.505
1zuaTOLAldo-keto reductase family 1 member B101.1.10.500
2pdq47DAldose reductase1.1.1.210.500
2pdu393Aldose reductase1.1.1.210.500
3b82NADExotoxin A2.4.2.360.485
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.485
1ry8RUTAldo-keto reductase family 1 member C3/0.468
2xuhTZ4Acetylcholinesterase3.1.1.70.460
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.460
4wevSUZAldo-keto reductase family 1 member B101.1.10.460
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.459
2v0mKLNCytochrome P450 3A4/0.457
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.457
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.455
5liu388Aldo-keto reductase family 1 member B101.1.10.455
1ry0PG2Aldo-keto reductase family 1 member C3/0.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.453
4msk2C8Tankyrase-12.4.2.300.453
2fzbTOLAldose reductase1.1.1.210.451
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.451
4e0u0MVCyclic dipeptide N-prenyltransferase/0.451
4tjy3GNTankyrase-22.4.2.300.451
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3f3y4OABile salt sulfotransferase2.8.2.140.450
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.450
4j7hTRHPCZA361.3/0.450
4k4eK4ETankyrase-12.4.2.300.450
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2xuoTZ4Acetylcholinesterase3.1.1.70.449
1dgbNDPCatalase1.11.1.60.448
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
4bjbP34Tankyrase-22.4.2.300.447
4bjcRPBTankyrase-22.4.2.300.447
4kmzFOLFolate receptor beta/0.447
1xk9P34Exotoxin A2.4.2.360.446
2d06ESTSulfotransferase 1A12.8.2.10.446
2xujTZ5Acetylcholinesterase3.1.1.70.446
2y6fM9FIsopenicillin N synthase1.21.3.10.446
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.446
3t0kDCQSulfide-quinone reductase/0.446
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.446
3sn6P0GBeta-2 adrenergic receptor/0.445
1e2lTMCThymidine kinase/0.444
2xuqTZ4Acetylcholinesterase3.1.1.70.444
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.443
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.443
4pnmNU1Tankyrase-22.4.2.300.443
2bfmTOPPteridine reductase 11.5.1.330.442
3akn11DFatty acid-binding protein, intestinal/0.442
3ghvGHCDihydrofolate reductase1.5.1.30.442
4li61XOTankyrase-12.4.2.300.442
1zgcA2EAcetylcholinesterase3.1.1.70.441
2cbqTH2Neocarzinostatin/0.441
2xukTZ5Acetylcholinesterase3.1.1.70.441
3gx9TXDMorphinone reductase/0.441
4dbs0HVAldo-keto reductase family 1 member C3/0.441
1h22E10Acetylcholinesterase3.1.1.70.440
1u08PLPMethionine aminotransferase/0.440
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3u9y09LTankyrase-22.4.2.300.440
3vf60H6Glucokinase2.7.1.20.440
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.440
4hmn16JAldo-keto reductase family 1 member C3/0.440