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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hyz42CHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hyz42CHeat shock protein HSP 90-alpha/1.000
1yc443PHeat shock protein HSP 90-alpha/0.574
2qg0A94Heat shock protein HSP 90-alpha/0.570
1yc14BCHeat shock protein HSP 90-alpha/0.558
3k974CDHeat shock protein HSP 90-alpha/0.530
2bz5AB4Heat shock protein HSP 90-alpha/0.529
3d0bSNXHeat shock protein HSP 90-alpha/0.529
3ekoPYUHeat shock protein HSP 90-alpha/0.509
2bt0CT5Heat shock protein HSP 90-alpha/0.506
3inxJZCHeat shock protein HSP 90-alpha/0.502
2xabVHDHeat shock protein HSP 90-alpha/0.496
2fwzH71Heat shock protein HSP 90-alpha/0.493
2yegXQGHeat shock protein HSP 90-alpha/0.488
3ekrPY9Heat shock protein HSP 90-alpha/0.487
2yee2ECHeat shock protein HSP 90-alpha/0.486
3hhu819Heat shock protein HSP 90-alpha/0.486
1uy7PU4Heat shock protein HSP 90-alpha/0.485
4bqjXKLHeat shock protein HSP 90-alpha/0.485
1uy9PU6Heat shock protein HSP 90-alpha/0.482
2fwyH64Heat shock protein HSP 90-alpha/0.480
3ft8MOJHeat shock protein HSP 90-alpha/0.480
1uymPU3Heat shock protein HSP 90-beta/0.479
4egh0OYHeat shock protein HSP 90-alpha/0.475
1yetGDMHeat shock protein HSP 90-alpha/0.472
2xd6XD6ATP-dependent molecular chaperone HSP82/0.470
1osfKOSHeat shock protein HSP 90-alpha/0.469
2ye42FYHeat shock protein HSP 90-alpha/0.468
4jqlVJ6Heat shock protein HSP 90-alpha/0.467
2bsmBSMHeat shock protein HSP 90-alpha/0.464
3o0iP54Heat shock protein HSP 90-alpha/0.464
3r4pFU7Heat shock protein HSP 90-alpha/0.464
1uykPUXHeat shock protein HSP 90-alpha/0.463
1yc34BCHeat shock protein HSP 90-alpha/0.463
2werRDCATP-dependent molecular chaperone HSP82/0.463
2wi5ZZ5Heat shock protein HSP 90-alpha/0.462
3whaWHAHeat shock protein HSP 90-alpha/0.462
2iwsNP4ATP-dependent molecular chaperone HSP82/0.461
2uwd2GGHeat shock protein HSP 90-alpha/0.461
4egkRDCHeat shock protein HSP 90-alpha/0.461
1qy5NECEndoplasmin/0.459
2yeiXQIHeat shock protein HSP 90-alpha/0.459
4bqg50QHeat shock protein HSP 90-alpha/0.459
3hekBD0Heat shock protein HSP 90-alpha/0.458
2h55DZ8Heat shock protein HSP 90-alpha/0.456
4xcjADPHeat shock cognate 90 kDa protein/0.456
2vcj2EQHeat shock protein HSP 90-alpha/0.455
3k99PFTHeat shock protein HSP 90-alpha/0.455
3vhaVHAHeat shock protein HSP 90-alpha/0.455
4hy6FJ1Heat shock protein HSP 90-alpha/0.455
2qfoA13Heat shock protein HSP 90-alpha/0.454
2xhrC0PHeat shock protein HSP 90-alpha/0.454
2wi72KLHeat shock protein HSP 90-alpha/0.453
4efuEFUHeat shock protein HSP 90-alpha/0.453
2byi2DDHeat shock protein HSP 90-alpha/0.452
4ipeANPTNF receptor-associated protein 1/0.452
4ivgANPTNF receptor-associated protein 1/0.452
1byqADPHeat shock protein HSP 90-alpha/0.451
2gqpPA7Endoplasmin/0.451
2wi4ZZ4Heat shock protein HSP 90-alpha/0.451
3hz5Z64Heat shock protein HSP 90-alpha/0.451
1uy8PU5Heat shock protein HSP 90-alpha/0.450
2vci2GJHeat shock protein HSP 90-alpha/0.450
2xcmADPCytosolic heat shock protein 90/0.449
3t10ACPHeat shock protein HSP 90-alpha/0.449
2yecXQ0Heat shock protein HSP 90-alpha/0.447
1qy8RDIEndoplasmin/0.446
1uyePU9Heat shock protein HSP 90-alpha/0.445
2byh2D7Heat shock protein HSP 90-alpha/0.445
1u2oNECEndoplasmin/0.444
3inwJZBHeat shock protein HSP 90-alpha/0.444
3rlq3RQHeat shock protein HSP 90-alpha/0.443
4xclAGSHeat shock cognate 90 kDa protein/0.441