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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2z6dFMNPhototropin-22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2z6dFMNPhototropin-22.7.11.11.000
4eetFMNPhototropin-22.7.11.10.588
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.559
3p7nFMNLight-activated DNA-binding protein EL222/0.554
3is2FADVivid PAS protein VVD/0.553
2pr5FMNBlue-light photoreceptor/0.551
3ue6FMNAureochrome1/0.551
2pdtFADVivid PAS protein VVD/0.544
3t50FMNBlue-light-activated histidine kinase2.7.13.30.535
1n9nFMNPutative blue light receptor/0.527
3sw1FMNSensory box protein/0.505
2pd7FADVivid PAS protein VVD/0.496
5dkkFMNPredicted protein/0.495
2pd8FADVivid PAS protein VVD/0.492
4eeuFMNPhototropin-22.7.11.10.491
5djtFMNNPH1-2/0.491
2z6cFMNPhototropin-12.7.11.10.486
4hhdFMNPhototropin-12.7.11.10.486
4eerFMNPhototropin-22.7.11.10.482
3icsCOACoenzyme A disulfide reductase/0.468
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.468
1n9lFMNPutative blue light receptor/0.467
4hj6FMNLOV protein/0.463
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.461
4kukRBFPutative blue-light photoreceptor/0.461
4ienCOAPutative acyl-CoA hydrolase/0.459
4nxvGDPMitochondrial dynamics protein MID51/0.459
1jpaANPEphrin type-B receptor 22.7.10.10.458
2j14GNIPeroxisome proliferator-activated receptor delta/0.458
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.458
1jipKTN6-deoxyerythronolide B hydroxylase/0.457
1ot7IU5Bile acid receptor/0.456
2npaMMBPeroxisome proliferator-activated receptor alpha/0.455
2p33J07Mitogen-activated protein kinase 102.7.11.240.455
3icrCOACoenzyme A disulfide reductase/0.455
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.454
2g8yNADHydroxycarboxylate dehydrogenase B/0.454
3gfbNADL-threonine 3-dehydrogenase/0.454
4eesFMNPhototropin-22.7.11.10.453
2bhiSFTCytotoxin 3/0.452
2ejvNADL-threonine 3-dehydrogenase/0.452
2q5g1FAPeroxisome proliferator-activated receptor delta/0.452
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.451
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.449
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.448
4lk3NADUDP-glucuronic acid decarboxylase 14.1.1.350.448
2po7CHDFerrochelatase, mitochondrial4.99.1.10.447
4eepFMNPhototropin-22.7.11.10.447
4lxhC1EAlpha/beta hydrolase fold/0.447
1kv2B96Mitogen-activated protein kinase 14/0.446
1qvrANPChaperone protein ClpB/0.446
3tqhNDPQuinone oxidoreductase/0.446
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.444
1udbUFGUDP-glucose 4-epimerase5.1.3.20.443
1xkdNAPIsocitrate dehydrogenase [NADP]/0.443
3s79ASDAromatase1.14.14.140.443
3b70NAPEnoyl reductase LovC10.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
1udaUFGUDP-glucose 4-epimerase5.1.3.20.441
2dvlFADAcyl-CoA dehydrogenase/0.441
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.441
4i02CMPcAMP-activated global transcriptional regulator CRP/0.441
2gjlFMNNitronate monooxygenase1.13.12.160.440
3sz0FADSulfide-quinone reductase/0.440
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.440
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.440