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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yi7BZ8Heat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2yi7BZ8Heat shock protein HSP 90-alpha/1.000
2uwd2GGHeat shock protein HSP 90-alpha/0.725
2bsmBSMHeat shock protein HSP 90-alpha/0.664
2yi66QMHeat shock protein HSP 90-alpha/0.651
2cct2E1Heat shock protein HSP 90-alpha/0.645
2wi1ZZ2Heat shock protein HSP 90-alpha/0.621
2wi5ZZ5Heat shock protein HSP 90-alpha/0.619
2vci2GJHeat shock protein HSP 90-alpha/0.616
2yecXQ0Heat shock protein HSP 90-alpha/0.597
4egh0OYHeat shock protein HSP 90-alpha/0.582
3ft5MO8Heat shock protein HSP 90-alpha/0.577
2wi2ZZ3Heat shock protein HSP 90-alpha/0.573
2vcj2EQHeat shock protein HSP 90-alpha/0.571
2yeiXQIHeat shock protein HSP 90-alpha/0.570
3d0bSNXHeat shock protein HSP 90-alpha/0.558
3hyz42CHeat shock protein HSP 90-alpha/0.554
2ye92D4Heat shock protein HSP 90-alpha/0.552
4egkRDCHeat shock protein HSP 90-alpha/0.552
2yjwYJWHeat shock protein HSP 90-alpha/0.547
2ye42FYHeat shock protein HSP 90-alpha/0.539
2qg0A94Heat shock protein HSP 90-alpha/0.532
1yc443PHeat shock protein HSP 90-alpha/0.529
2xjxXJXHeat shock protein HSP 90-alpha/0.528
4xclAGSHeat shock cognate 90 kDa protein/0.523
1uy8PU5Heat shock protein HSP 90-alpha/0.517
1uy7PU4Heat shock protein HSP 90-alpha/0.515
3o0iP54Heat shock protein HSP 90-alpha/0.515
1uykPUXHeat shock protein HSP 90-alpha/0.514
2yegXQGHeat shock protein HSP 90-alpha/0.514
1yc14BCHeat shock protein HSP 90-alpha/0.510
1yetGDMHeat shock protein HSP 90-alpha/0.509
4ipeANPTNF receptor-associated protein 1/0.509
1uy9PU6Heat shock protein HSP 90-alpha/0.507
3k974CDHeat shock protein HSP 90-alpha/0.501
2xjjL81Heat shock protein HSP 90-alpha/0.499
1osfKOSHeat shock protein HSP 90-alpha/0.495
2ccu2D9Heat shock protein HSP 90-alpha/0.492
4awq592Heat shock protein HSP 90-alpha/0.492
4xcjADPHeat shock cognate 90 kDa protein/0.492
2wi6ZZ6Heat shock protein HSP 90-alpha/0.490
2yejXQKHeat shock protein HSP 90-alpha/0.489
2yejZZ3Heat shock protein HSP 90-alpha/0.486
3t10ACPHeat shock protein HSP 90-alpha/0.486
2bt0CT5Heat shock protein HSP 90-alpha/0.483
3k981RCHeat shock protein HSP 90-alpha/0.482
2bz5AB4Heat shock protein HSP 90-alpha/0.480
3vhaVHAHeat shock protein HSP 90-alpha/0.480
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.479
3whaWHAHeat shock protein HSP 90-alpha/0.477
2xabVHDHeat shock protein HSP 90-alpha/0.476
2xhrC0PHeat shock protein HSP 90-alpha/0.475
4jqlVJ6Heat shock protein HSP 90-alpha/0.473
2xcmADPCytosolic heat shock protein 90/0.472
3qtqX35Cyclin-dependent kinase 22.7.11.220.471
4ivgANPTNF receptor-associated protein 1/0.467
2xd6XD6ATP-dependent molecular chaperone HSP82/0.466
4xdmGDMHeat shock cognate 90 kDa protein/0.465
2xk2ADPHeat shock protein HSP 90-alpha/0.462
3inwJZBHeat shock protein HSP 90-alpha/0.462
1byqADPHeat shock protein HSP 90-alpha/0.461
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.461
2iorADPChaperone protein HtpG/0.460
3opdHIEHeat shock protein 83/0.459
2gqpPA7Endoplasmin/0.456
2o1vADPEndoplasmin/0.455
4qmpDKISerine/threonine-protein kinase 242.7.11.10.455
1h1s4SPCyclin-dependent kinase 22.7.11.220.454
3l9hEMQKinesin-like protein KIF11/0.454
3r4oFU3Heat shock protein HSP 90-alpha/0.454
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.452
3rlq3RQHeat shock protein HSP 90-alpha/0.452
4ce17FKATP-dependent molecular chaperone HSP82/0.452
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.452
1suoCPZCytochrome P450 2B41.14.14.10.449
2breKJ2ATP-dependent molecular chaperone HSP82/0.449
4asg814ATP-dependent molecular chaperone HSP82/0.449
4egiB2JHeat shock protein HSP 90-alpha/0.449
2iwsNP4ATP-dependent molecular chaperone HSP82/0.448
2uzlC94Cyclin-dependent kinase 22.7.11.220.448
3ekoPYUHeat shock protein HSP 90-alpha/0.448
2q5oTPWIndole-3-pyruvate decarboxylase4.1.1.740.447
4fcr0TMHeat shock protein HSP 90-alpha/0.447
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2wxvWXVCyclin-dependent kinase 22.7.11.220.446
3ictFADCoenzyme A disulfide reductase/0.446
1nhhANPDNA mismatch repair protein MutL/0.445
1o76CAMCamphor 5-monooxygenase1.14.15.10.445
2fznFADBifunctional protein PutA1.5.5.20.445
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.445
3s1dZIRCytokinin dehydrogenase 11.5.99.120.445
4a8v2ANMajor pollen allergen Bet v 1-J/0.445
4j1tNADNAD/NADP transhydrogenase alpha subunit 1/0.445
4qmzB49Serine/threonine-protein kinase 242.7.11.10.445
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
2qblCAMCamphor 5-monooxygenase1.14.15.10.444
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3saa77FProtease/0.444
4q71FADBifunctional protein PutA/0.444
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.444
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.443
1t88CAMCamphor 5-monooxygenase1.14.15.10.443
2p5uNADUDP-glucose 4-epimerase/0.443
3h6vNS6Glutamate receptor 2/0.443
4du82P0Mevalonate diphosphate decarboxylase/0.443
1l4mNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.441
1nzdUPGDNA beta-glucosyltransferase/0.441
3lqfNADGalactitol dehydrogenase/0.441
3od0PCGcGMP-dependent protein kinase 12.7.11.120.441
2xbmSAHGenome polyprotein/0.440
3hx4ANPCalmodulin-domain protein kinase 1/0.440