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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.11.000
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.682
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.644
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.641
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.639
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.619
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.613
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.607
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.591
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.590
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.565
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.564
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.562
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.549
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.536
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.517
4jbpYPHAurora kinase A2.7.11.10.516
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.515
4jboWPHAurora kinase A2.7.11.10.494
5av2KMPDeath-associated protein kinase 12.7.11.10.485
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.483
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.483
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.478
2ckeIQUDeath-associated protein kinase 2/0.477
2vrx447Aurora kinase B-A2.7.11.10.476
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.475
2c6eHPMAurora kinase A2.7.11.10.474
4wsqKSAAP2-associated protein kinase 12.7.11.10.474
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.473
4b99R4LMitogen-activated protein kinase 72.7.11.240.469
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.469
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.466
3ztxZTXAurora kinase B-A2.7.11.10.466
4ysjADPCalmodulin-like domain protein kinase/0.466
5av3KMPDeath-associated protein kinase 12.7.11.10.465
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.463
4jbqVX6Aurora kinase A2.7.11.10.463
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3w2sW2REpidermal growth factor receptor2.7.10.10.461
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.461
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.461
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.460
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.457
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.457
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.455
3bu5ATPInsulin receptor2.7.10.10.454
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.454
3k5uPFQAurora kinase A2.7.11.10.453
3gu7ADPDeath-associated protein kinase 12.7.11.10.452
1ig1ANPDeath-associated protein kinase 12.7.11.10.451
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.451
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.450
4jia1K3Tyrosine-protein kinase JAK2/0.450
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.449
3bqr4RBDeath-associated protein kinase 3/0.447
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.447
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.446
3gu83GUDeath-associated protein kinase 12.7.11.10.446
3vs1VSATyrosine-protein kinase HCK2.7.10.20.446
4o0uADNAurora kinase A2.7.11.10.446
2j0lANPFocal adhesion kinase 12.7.10.20.445
3hx4ANPCalmodulin-domain protein kinase 1/0.445
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.445
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.445
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.445
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.443
4gt3ATPMitogen-activated protein kinase 12.7.11.240.443
3rak03ZCyclin-dependent kinase 22.7.11.220.442
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440