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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.11.000
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.522
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.513
4fv6E57Mitogen-activated protein kinase 12.7.11.240.510
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.502
3i60E86Mitogen-activated protein kinase 12.7.11.240.502
3rak03ZCyclin-dependent kinase 22.7.11.220.486
4ehzJAKTyrosine-protein kinase JAK1/0.483
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.483
3qxpX64Cyclin-dependent kinase 22.7.11.220.482
3s1h56ZCyclin-dependent kinase 22.7.11.220.482
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.481
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.480
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.478
4bcmT7ZCyclin-dependent kinase 22.7.11.220.478
4hge15VTyrosine-protein kinase JAK2/0.478
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.477
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.475
4dgnLU2Casein kinase II subunit alpha2.7.11.10.473
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.473
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.472
4f081RSTyrosine-protein kinase JAK2/0.472
4ji91M3Tyrosine-protein kinase JAK2/0.472
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.470
4e6d0NUTyrosine-protein kinase JAK2/0.470
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.469
2pvhP19Casein kinase II subunit alpha2.7.11.10.469
2vv9IM9Cyclin-dependent kinase 22.7.11.220.469
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.469
4i5cC5ITyrosine-protein kinase JAK1/0.468
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.465
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.464
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3sw719KCyclin-dependent kinase 22.7.11.220.463
5e8ySTUTGF-beta receptor type-22.7.11.300.463
2vu3LZECyclin-dependent kinase 22.7.11.220.461
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.461
3at4CCKCasein kinase II subunit alpha2.7.11.10.461
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.461
4aqc88ATyrosine-protein kinase JAK2/0.461
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.461
2c6lDT4Cyclin-dependent kinase 22.7.11.220.460
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.460
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
4qnyANPMitogen activated protein kinase, putative/0.459
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.458
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.456
2w17I19Cyclin-dependent kinase 22.7.11.220.456
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4dgmAGICasein kinase II subunit alpha2.7.11.10.455
1fvv107Cyclin-dependent kinase 22.7.11.220.454
3nynSGVG protein-coupled receptor kinase 62.7.11.160.454
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.454
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.453
1jklANPDeath-associated protein kinase 12.7.11.10.453
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3gu83GUDeath-associated protein kinase 12.7.11.10.453
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
2uzbC75Cyclin-dependent kinase 22.7.11.220.452
3eb0DRKUncharacterized protein/0.452
3my5RFZCyclin-dependent kinase 22.7.11.220.452
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4aguD15Cyclin-dependent kinase-like 1/0.451
4fv9E71Mitogen-activated protein kinase 12.7.11.240.451
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.449
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.449
4y93746Tyrosine-protein kinase/0.449
1oitHDTCyclin-dependent kinase 22.7.11.220.448
1w0xOLOCyclin-dependent kinase 22.7.11.220.448
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4hvi19STyrosine-protein kinase JAK32.7.10.20.448
1gii1PUCyclin-dependent kinase 22.7.11.220.447
3raiX85Cyclin-dependent kinase 22.7.11.220.447
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.447
3rkb12ZCyclin-dependent kinase 22.7.11.220.446
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.445
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.445
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.445
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.445
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.444
1pxmCK5Cyclin-dependent kinase 22.7.11.220.443
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3nux3NVCyclin-dependent kinase 62.7.11.220.443
4grb0XGCasein kinase II subunit alpha2.7.11.10.443
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.442
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3zh8C58Protein kinase C iota type2.7.11.130.442
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.442
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2btsU32Cyclin-dependent kinase 22.7.11.220.440
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.440
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.440
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440
5av2KMPDeath-associated protein kinase 12.7.11.10.440