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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.658
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.648
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.642
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.626
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.616
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.613
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.606
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.602
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.590
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.578
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.564
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.554
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.544
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.543
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.540
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.535
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.525
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.523
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.509
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.498
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.497
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.486
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.486
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3mvjXFEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.455
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2f2uM77Rho-associated protein kinase 22.7.11.10.450
3bqr4RBDeath-associated protein kinase 3/0.449
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.447
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.445
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.445
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.442
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.442
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2ckeIQUDeath-associated protein kinase 2/0.440
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440