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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.709
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.683
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.647
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.647
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.646
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.642
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.640
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.638
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.636
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.630
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.629
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.625
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.624
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.611
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.607
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.606
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.602
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.595
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.590
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.577
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.576
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.563
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.558
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.553
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.549
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.548
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.544
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.535
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.534
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.530
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.523
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.457
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.457
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.454
4qnyANPMitogen activated protein kinase, putative/0.453
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4ysjADPCalmodulin-like domain protein kinase/0.447
2ckeIQUDeath-associated protein kinase 2/0.444
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444