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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2r3r6SCCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2r3r6SCCyclin-dependent kinase 22.7.11.221.000
2r3iSCFCyclin-dependent kinase 22.7.11.220.662
2r3o2SCCyclin-dependent kinase 22.7.11.220.641
2c6iDT1Cyclin-dependent kinase 22.7.11.220.597
4fkt48KCyclin-dependent kinase 22.7.11.220.573
4ek610KCyclin-dependent kinase 22.7.11.220.557
2r3gSC9Cyclin-dependent kinase 22.7.11.220.549
2r3q5SCCyclin-dependent kinase 22.7.11.220.547
1w8cN69Cyclin-dependent kinase 22.7.11.220.538
2r3mSCXCyclin-dependent kinase 22.7.11.220.536
2r3p3SCCyclin-dependent kinase 22.7.11.220.534
3r1yX76Cyclin-dependent kinase 22.7.11.220.533
4ek816KCyclin-dependent kinase 22.7.11.220.531
4kd11QKCyclin-dependent kinase 22.7.11.220.531
1b39ATPCyclin-dependent kinase 22.7.11.220.530
2btrU73Cyclin-dependent kinase 22.7.11.220.527
2r3fSC8Cyclin-dependent kinase 22.7.11.220.526
2c69CT8Cyclin-dependent kinase 22.7.11.220.525
4fklCK2Cyclin-dependent kinase 22.7.11.220.523
3r8vZ62Cyclin-dependent kinase 22.7.11.220.522
3rahO1ZCyclin-dependent kinase 22.7.11.220.518
2c6mDT5Cyclin-dependent kinase 22.7.11.220.515
1h0vUN4Cyclin-dependent kinase 22.7.11.220.513
1pxmCK5Cyclin-dependent kinase 22.7.11.220.513
1h0w207Cyclin-dependent kinase 22.7.11.220.511
1y8yCT7Cyclin-dependent kinase 22.7.11.220.507
3lfqA28Cyclin-dependent kinase 22.7.11.220.506
2c6o4SPCyclin-dependent kinase 22.7.11.220.505
3iggEFQCyclin-dependent kinase 22.7.11.220.504
4fkq42KCyclin-dependent kinase 22.7.11.220.504
3lfsA07Cyclin-dependent kinase 22.7.11.220.502
1ke5LS1Cyclin-dependent kinase 22.7.11.220.501
3qqlX03Cyclin-dependent kinase 22.7.11.220.501
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.499
3sw719KCyclin-dependent kinase 22.7.11.220.498
2j9mPY8Cyclin-dependent kinase 22.7.11.220.497
3r7yZ04Cyclin-dependent kinase 22.7.11.220.496
3raiX85Cyclin-dependent kinase 22.7.11.220.496
3rm719ZCyclin-dependent kinase 22.7.11.220.495
1vyzN5BCyclin-dependent kinase 22.7.11.220.494
3r9nZ68Cyclin-dependent kinase 22.7.11.220.493
1w0xOLOCyclin-dependent kinase 22.7.11.220.492
3r73X87Cyclin-dependent kinase 22.7.11.220.492
1ykr628Cyclin-dependent kinase 22.7.11.220.489
2w05FRTCyclin-dependent kinase 22.7.11.220.487
3rni21ZCyclin-dependent kinase 22.7.11.220.486
4fkpLS5Cyclin-dependent kinase 22.7.11.220.485
1oitHDTCyclin-dependent kinase 22.7.11.220.484
2vthLZ2Cyclin-dependent kinase 22.7.11.220.481
3r7vZ02Cyclin-dependent kinase 22.7.11.220.481
4fkg4CKCyclin-dependent kinase 22.7.11.220.480
4fki09KCyclin-dependent kinase 22.7.11.220.479
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.478
3qwjX6ACyclin-dependent kinase 22.7.11.220.478
2uzoC62Cyclin-dependent kinase 22.7.11.220.477
2c6lDT4Cyclin-dependent kinase 22.7.11.220.476
3qqhX0ACyclin-dependent kinase 22.7.11.220.475
2a4lRRCCyclin-dependent kinase 22.7.11.220.474
2btsU32Cyclin-dependent kinase 22.7.11.220.474
3r7uX96Cyclin-dependent kinase 22.7.11.220.474
3r8lZ30Cyclin-dependent kinase 22.7.11.220.474
3r83Z14Cyclin-dependent kinase 22.7.11.220.473
3rak03ZCyclin-dependent kinase 22.7.11.220.473
3s2pPMUCyclin-dependent kinase 22.7.11.220.473
2c6kDT2Cyclin-dependent kinase 22.7.11.220.472
1e1xNW1Cyclin-dependent kinase 22.7.11.220.471
2exmZIPCyclin-dependent kinase 22.7.11.220.471
3lfnA27Cyclin-dependent kinase 22.7.11.220.470
3ezvEZVCyclin-dependent kinase 22.7.11.220.469
3qruX19Cyclin-dependent kinase 22.7.11.220.469
2a0cCK9Cyclin-dependent kinase 22.7.11.220.467
4fkr45KCyclin-dependent kinase 22.7.11.220.465
1gih1PUCyclin-dependent kinase 22.7.11.220.464
3qtsX46Cyclin-dependent kinase 22.7.11.220.464
3qxoX65Cyclin-dependent kinase 22.7.11.220.464
3s1h56ZCyclin-dependent kinase 22.7.11.220.464
3ig7EFPCyclin-dependent kinase 22.7.11.220.462
3qxpX64Cyclin-dependent kinase 22.7.11.220.462
1pxpCK8Cyclin-dependent kinase 22.7.11.220.461
4bgh3I6Cyclin-dependent kinase 22.7.11.220.460
3qx2X63Cyclin-dependent kinase 22.7.11.220.459
3r8uZ31Cyclin-dependent kinase 22.7.11.220.459
2uznC96Cyclin-dependent kinase 22.7.11.220.457
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.457
3qtuX44Cyclin-dependent kinase 22.7.11.220.457
3qzgX67Cyclin-dependent kinase 22.7.11.220.457
2r3kSCQCyclin-dependent kinase 22.7.11.220.456
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.456
2w17I19Cyclin-dependent kinase 22.7.11.220.455
3fz1B98Cyclin-dependent kinase 22.7.11.220.453
3pxyJWSCyclin-dependent kinase 22.7.11.220.453
2bhhRYUCyclin-dependent kinase 22.7.11.220.452
2fvdLIACyclin-dependent kinase 22.7.11.220.452
3rpv26ZCyclin-dependent kinase 22.7.11.220.452
1b38ATPCyclin-dependent kinase 22.7.11.220.451
2vtsLZCCyclin-dependent kinase 22.7.11.220.451
3rm618ZCyclin-dependent kinase 22.7.11.220.451
3rpo24ZCyclin-dependent kinase 22.7.11.220.451
4fx360KCyclin-dependent kinase 22.7.11.220.451
3r28XA0Cyclin-dependent kinase 22.7.11.220.450
3qtrX36Cyclin-dependent kinase 22.7.11.220.449
3qqkX02Cyclin-dependent kinase 22.7.11.220.448
3r9hZ67Cyclin-dependent kinase 22.7.11.220.448
1gz8MBPCyclin-dependent kinase 22.7.11.220.447
4fko20KCyclin-dependent kinase 22.7.11.220.447
1gii1PUCyclin-dependent kinase 22.7.11.220.446
3my5RFZCyclin-dependent kinase 22.7.11.220.446
3wblPDYCyclin-dependent kinase 22.7.11.220.445
2r3lSCWCyclin-dependent kinase 22.7.11.220.444
3r7iX9ICyclin-dependent kinase 22.7.11.220.444
1ke7LS3Cyclin-dependent kinase 22.7.11.220.443
4ii5ADPCyclin-dependent kinase 22.7.11.220.443
3rk909ZCyclin-dependent kinase 22.7.11.220.442
3sqq99ZCyclin-dependent kinase 22.7.11.220.442
2w1hL0FCyclin-dependent kinase 22.7.11.220.441
3qtqX35Cyclin-dependent kinase 22.7.11.220.441
1fvt106Cyclin-dependent kinase 22.7.11.220.440
1oirHDYCyclin-dependent kinase 22.7.11.220.440
1p2a5BNCyclin-dependent kinase 22.7.11.220.440
4ez30S0Cyclin-dependent kinase 22.7.11.220.440