sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pr5 | FMN | Blue-light photoreceptor |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2pr5 | FMN | Blue-light photoreceptor | / | 1.000 | |
| 3t50 | FMN | Blue-light-activated histidine kinase | 2.7.13.3 | 0.594 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.588 | |
| 4wuj | FMN | Glycoside hydrolase family 15, cellulose signaling associated protein envoy | / | 0.578 | |
| 3ue6 | FMN | Aureochrome1 | / | 0.574 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.569 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.558 | |
| 4hhd | FMN | Phototropin-1 | 2.7.11.1 | 0.529 | |
| 3is2 | FAD | Vivid PAS protein VVD | / | 0.518 | |
| 4eeu | FMN | Phototropin-2 | 2.7.11.1 | 0.514 | |
| 2pdt | FAD | Vivid PAS protein VVD | / | 0.512 | |
| 5djt | FMN | NPH1-2 | / | 0.502 | |
| 1n9l | FMN | Putative blue light receptor | / | 0.494 | |
| 1n9n | FMN | Putative blue light receptor | / | 0.481 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.480 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.474 | |
| 3sw1 | FMN | Sensory box protein | / | 0.473 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.469 | |
| 5dkk | FMN | Predicted protein | / | 0.469 | |
| 4r38 | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.468 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.467 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.467 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.465 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.462 | |
| 4hj6 | FMN | LOV protein | / | 0.461 | |
| 1nvm | NAD | Acetaldehyde dehydrogenase | 1.2.1.10 | 0.459 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.456 | |
| 2pd7 | FAD | Vivid PAS protein VVD | / | 0.455 | |
| 5j4e | FMN | Sensory box protein | / | 0.455 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 2pd8 | FAD | Vivid PAS protein VVD | / | 0.453 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.451 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.450 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 2mwg | FMN | Blue-light photoreceptor | / | 0.448 | |
| 3liv | E16 | Protease | / | 0.447 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.447 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.446 | |
| 4ees | FMN | Phototropin-2 | 2.7.11.1 | 0.446 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.446 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.446 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 5j3w | FMN | Sensory box protein | / | 0.445 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.444 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.444 | |
| 4eep | FMN | Phototropin-2 | 2.7.11.1 | 0.444 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.443 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2cdu | FAD | NADH oxidase | / | 0.443 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.443 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.443 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.443 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.442 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.441 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.441 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.440 |