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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gr0FADFerredoxin reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2gr0FADFerredoxin reductase/1.000
2gqwFADFerredoxin reductase/0.796
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.779
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.665
1d7yFADFerredoxin reductase/0.657
2gr1FADFerredoxin reductase/0.657
4h4rFADBiphenyl dioxygenase ferredoxin reductase subunit/0.641
4h4tFADBiphenyl dioxygenase ferredoxin reductase subunit/0.635
2gr3FADFerredoxin reductase/0.610
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.608
4h4wFADBiphenyl dioxygenase ferredoxin reductase subunit/0.594
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.589
4h4pFADBiphenyl dioxygenase ferredoxin reductase subunit/0.558
5fs6FADApoptosis-inducing factor 1, mitochondrial1.1.10.523
5fs9FADApoptosis-inducing factor 1, mitochondrial1.1.10.523
4h4yFADBiphenyl dioxygenase ferredoxin reductase subunit/0.518
4bv6FADApoptosis-inducing factor 1, mitochondrial1.1.10.500
4emjFADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.498
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.496
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.495
1m6iFADApoptosis-inducing factor 1, mitochondrial1.1.10.492
5fs8FADApoptosis-inducing factor 1, mitochondrial1.1.10.489
2yvjFADFerredoxin reductase/0.484
4liiFADApoptosis-inducing factor 1, mitochondrial1.1.10.484
3ic9FADPutative dihydrolipoamide dehydrogenase/0.482
1f3pFADFerredoxin reductase/0.476
2cduFADNADH oxidase/0.473
3lxdFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.472
1nhsFADNADH peroxidase1.11.1.10.465
3cgcFADCoenzyme A disulfide reductase/0.462
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.461
1nhqFADNADH peroxidase1.11.1.10.460
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.460
1nhpFADNADH peroxidase1.11.1.10.459
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.457
2eq9FADDihydrolipoyl dehydrogenase/0.454
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.448
3lb8FADPutidaredoxin reductase1.18.1.50.444
1f8wFADNADH peroxidase1.11.1.10.443
1gv4FADApoptosis-inducing factor 1, mitochondrial1.1.10.443
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.443
2eq8FADDihydrolipoyl dehydrogenase/0.440