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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c6kDT2Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c6kDT2Cyclin-dependent kinase 22.7.11.221.000
1y8yCT7Cyclin-dependent kinase 22.7.11.220.593
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.566
3r8vZ62Cyclin-dependent kinase 22.7.11.220.557
4fklCK2Cyclin-dependent kinase 22.7.11.220.557
1oitHDTCyclin-dependent kinase 22.7.11.220.537
3r71X86Cyclin-dependent kinase 22.7.11.220.536
3r7yZ04Cyclin-dependent kinase 22.7.11.220.536
1w8cN69Cyclin-dependent kinase 22.7.11.220.535
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.533
3rahO1ZCyclin-dependent kinase 22.7.11.220.532
2exmZIPCyclin-dependent kinase 22.7.11.220.529
3lfqA28Cyclin-dependent kinase 22.7.11.220.527
2c6lDT4Cyclin-dependent kinase 22.7.11.220.526
2r3iSCFCyclin-dependent kinase 22.7.11.220.526
2c6o4SPCyclin-dependent kinase 22.7.11.220.524
3r1yX76Cyclin-dependent kinase 22.7.11.220.524
3r83Z14Cyclin-dependent kinase 22.7.11.220.521
3r8lZ30Cyclin-dependent kinase 22.7.11.220.520
2btrU73Cyclin-dependent kinase 22.7.11.220.519
2vtrLZBCyclin-dependent kinase 22.7.11.220.518
3lfnA27Cyclin-dependent kinase 22.7.11.220.516
2vtsLZCCyclin-dependent kinase 22.7.11.220.514
3qzgX67Cyclin-dependent kinase 22.7.11.220.514
2a4lRRCCyclin-dependent kinase 22.7.11.220.512
4ek610KCyclin-dependent kinase 22.7.11.220.508
4kd11QKCyclin-dependent kinase 22.7.11.220.505
1ykr628Cyclin-dependent kinase 22.7.11.220.504
2b53D23Cyclin-dependent kinase 22.7.11.220.504
4ek816KCyclin-dependent kinase 22.7.11.220.501
1pxjCK2Cyclin-dependent kinase 22.7.11.220.500
4fkq42KCyclin-dependent kinase 22.7.11.220.496
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.495
1oirHDYCyclin-dependent kinase 22.7.11.220.493
2uzoC62Cyclin-dependent kinase 22.7.11.220.493
4fkpLS5Cyclin-dependent kinase 22.7.11.220.493
1pxlCK4Cyclin-dependent kinase 22.7.11.220.489
3s2pPMUCyclin-dependent kinase 22.7.11.220.489
4fkt48KCyclin-dependent kinase 22.7.11.220.489
1pxmCK5Cyclin-dependent kinase 22.7.11.220.488
2a0cCK9Cyclin-dependent kinase 22.7.11.220.488
2r3jSCJCyclin-dependent kinase 22.7.11.220.488
3rpo24ZCyclin-dependent kinase 22.7.11.220.486
4fki09KCyclin-dependent kinase 22.7.11.220.486
3r9dX6BCyclin-dependent kinase 22.7.11.220.485
3rk708ZCyclin-dependent kinase 22.7.11.220.485
2ds11CDCyclin-dependent kinase 22.7.11.220.484
3r7uX96Cyclin-dependent kinase 22.7.11.220.483
3qtxX43Cyclin-dependent kinase 22.7.11.220.481
1ke5LS1Cyclin-dependent kinase 22.7.11.220.479
2vthLZ2Cyclin-dependent kinase 22.7.11.220.477
2vtqLZACyclin-dependent kinase 22.7.11.220.477
1hckATPCyclin-dependent kinase 22.7.11.220.474
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.474
4fkv61KCyclin-dependent kinase 22.7.11.220.473
3rjc06ZCyclin-dependent kinase 22.7.11.220.472
1y91CT9Cyclin-dependent kinase 22.7.11.220.470
3qu0X40Cyclin-dependent kinase 22.7.11.220.469
2uznC96Cyclin-dependent kinase 22.7.11.220.468
3rni21ZCyclin-dependent kinase 22.7.11.220.468
4fks46KCyclin-dependent kinase 22.7.11.220.468
1g5sI17Cyclin-dependent kinase 22.7.11.220.466
2c6iDT1Cyclin-dependent kinase 22.7.11.220.466
3qwjX6ACyclin-dependent kinase 22.7.11.220.465
3qqlX03Cyclin-dependent kinase 22.7.11.220.464
1e1xNW1Cyclin-dependent kinase 22.7.11.220.462
3rk909ZCyclin-dependent kinase 22.7.11.220.462
1ke9LS5Cyclin-dependent kinase 22.7.11.220.460
1pxoCK7Cyclin-dependent kinase 22.7.11.220.459
3qtuX44Cyclin-dependent kinase 22.7.11.220.455
3s1h56ZCyclin-dependent kinase 22.7.11.220.455
2b52D42Cyclin-dependent kinase 22.7.11.220.452
2xmyCDKCyclin-dependent kinase 22.7.11.220.452
3rkb12ZCyclin-dependent kinase 22.7.11.220.452
4fkg4CKCyclin-dependent kinase 22.7.11.220.452
2r3lSCWCyclin-dependent kinase 22.7.11.220.446
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.445
2w06FRVCyclin-dependent kinase 22.7.11.220.445
3nieANPMitogen-activated protein kinase/0.445
3r9nZ68Cyclin-dependent kinase 22.7.11.220.445
1h0w207Cyclin-dependent kinase 22.7.11.220.444
3rpv26ZCyclin-dependent kinase 22.7.11.220.444
3sqq99ZCyclin-dependent kinase 22.7.11.220.444
2r3r6SCCyclin-dependent kinase 22.7.11.220.443
3iggEFQCyclin-dependent kinase 22.7.11.220.443
3rm618ZCyclin-dependent kinase 22.7.11.220.442
2btsU32Cyclin-dependent kinase 22.7.11.220.440