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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ankANPAdenylate kinase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ankANPAdenylate kinase/1.000
4qbiAP5Adenylate kinase/0.627
1akeAP5Adenylate kinase/0.591
3hpqAP5Adenylate kinase/0.588
4x8oAP5Adenylate kinase/0.587
1p3jAP5Adenylate kinase/0.562
2oo7AP5Adenylate kinase/0.558
3dkvAP5Adenylate kinase/0.554
4jl5ADPAdenylate kinase/0.550
4qbhAP5Adenylate kinase/0.535
4jl6ADPAdenylate kinase/0.530
2qajAP5Adenylate kinase/0.525
2eckADPAdenylate kinase/0.523
4w5jAP5Adenylate kinase/0.521
4nu0AP5Adenylate kinase/0.516
4x8lAP5Adenylate kinase/0.502
4mkgAP5Adenylate kinase/0.500
1zioAP5Adenylate kinase/0.493
2akyAP5Adenylate kinase/0.490
2rgxAP5Adenylate kinase/0.475
4mkfAP5Adenylate kinase/0.472
2olrATPPhosphoenolpyruvate carboxykinase (ATP)/0.469
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.468
4loh1SYStimulator of interferon genes protein/0.459
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.459
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.458
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.456
4yp12BAStimulator of interferon genes protein/0.456
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.455
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.454
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.454
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
4jkyADPAdenylate kinase/0.451
5c3rHMUThymine dioxygenase/0.451
1gv0NADMalate dehydrogenase/0.450
3au2DGTDNA polymerase beta family (X family)/0.449
2cbsR13Cellular retinoic acid-binding protein 2/0.448
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.448
1svmATPLarge T antigen3.6.40.447
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
1xelUPGUDP-glucose 4-epimerase5.1.3.20.446
4eqrFADCoenzyme A disulfide reductase/0.446
1ytmATPPhosphoenolpyruvate carboxykinase (ATP)/0.445
2omeNADC-terminal-binding protein 2/0.445
3lqfNADGalactitol dehydrogenase/0.445
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.444
1p9wANPType II secretion system protein E/0.444
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
3zeiAWHO-acetylserine sulfhydrylase/0.444
1nhrFADNADH peroxidase1.11.1.10.443
3tn7NJPShort-chain alcohol dehydrogenase/0.443
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.443
4loi1YCStimulator of interferon genes protein/0.442
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.441
1tqf32PBeta-secretase 13.4.23.460.441
2nliFMNLactate oxidase/0.441
2vprTDCTetracycline repressor protein class H/0.441
2yvfNADFerredoxin reductase/0.441
4a6nFADTetX family tetracycline inactivation enzyme/0.441
4ikeADPAdenylate kinase/0.441