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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5dt0SKEAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5dt0SKEAurora kinase A2.7.11.11.000
5dpvSKEAurora kinase A2.7.11.10.639
5dr9SKEAurora kinase A2.7.11.10.632
4o0wADNAurora kinase A2.7.11.10.529
2x6dX6DAurora kinase A2.7.11.10.526
5dr6SKEAurora kinase A2.7.11.10.525
2xru400Aurora kinase A2.7.11.10.506
4deaNHIAurora kinase A2.7.11.10.503
2dwbANPAurora kinase A2.7.11.10.492
3uo50BXAurora kinase A2.7.11.10.483
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
2w1fL0FAurora kinase A2.7.11.10.480
2np8CC3Aurora kinase A2.7.11.10.479
3a62STURibosomal protein S6 kinase beta-12.7.11.10.477
3k5uPFQAurora kinase A2.7.11.10.477
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.475
3w18N13Aurora kinase A2.7.11.10.475
3zep1NXTyrosine-protein kinase JAK32.7.10.20.475
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.475
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.471
3ggfGVDSerine/threonine-protein kinase 26/0.471
4o0sADNAurora kinase A2.7.11.10.471
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.469
4o0uADNAurora kinase A2.7.11.10.469
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.467
4bbfO19Tyrosine-protein kinase JAK2/0.467
5drdATPAurora kinase A2.7.11.10.467
2j9mPY8Cyclin-dependent kinase 22.7.11.220.466
4jajXU1Aurora kinase A2.7.11.10.464
4q73FADBifunctional protein PutA/0.463
1ol5ADPAurora kinase A2.7.11.10.462
2xngA0HAurora kinase A2.7.11.10.462
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.462
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.462
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.462
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.462
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.461
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.460
4acm7YGCyclin-dependent kinase 22.7.11.220.460
1fvv107Cyclin-dependent kinase 22.7.11.220.459
4bgh3I6Cyclin-dependent kinase 22.7.11.220.459
4jbqVX6Aurora kinase A2.7.11.10.459
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.458
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.456
1xddAAYIntegrin alpha-L/0.455
2w1eL0EAurora kinase A2.7.11.10.455
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.455
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.454
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.453
2r3kSCQCyclin-dependent kinase 22.7.11.220.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.452
4fkr45KCyclin-dependent kinase 22.7.11.220.452
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.450
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.450
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1wvxBD4Death-associated protein kinase 12.7.11.10.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4hvh19RTyrosine-protein kinase JAK32.7.10.20.448
4hvi19STyrosine-protein kinase JAK32.7.10.20.448
4jbpYPHAurora kinase A2.7.11.10.448
4wboANWRhodopsin kinase/0.448
2b7aIZATyrosine-protein kinase JAK2/0.447
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.447
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.447
4utdACPAurora kinase A2.7.11.10.447
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.446
1pxpCK8Cyclin-dependent kinase 22.7.11.220.445
2b55D31Cyclin-dependent kinase 22.7.11.220.445
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.444
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.444
5dt3ATPAurora kinase A2.7.11.10.444
1g5sI17Cyclin-dependent kinase 22.7.11.220.443
1pxmCK5Cyclin-dependent kinase 22.7.11.220.443
1y91CT9Cyclin-dependent kinase 22.7.11.220.443
4b8lA0PAurora kinase B-A2.7.11.10.443
4ivc1J6Tyrosine-protein kinase JAK1/0.443
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.442
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
5dt4ATPAurora kinase A2.7.11.10.442
2a0cCK9Cyclin-dependent kinase 22.7.11.220.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
4e6d0NUTyrosine-protein kinase JAK2/0.441
4gmy0X5Tyrosine-protein kinase JAK2/0.441
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.441
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.441
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.440
4c3rACPAurora kinase A2.7.11.10.440
4fx360KCyclin-dependent kinase 22.7.11.220.440
4hvg19QTyrosine-protein kinase JAK32.7.10.20.440
4q72FADBifunctional protein PutA/0.440