sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5ayj | MUA | Uric acid degradation bifunctional protein | 1.7.3.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5ayj | MUA | Uric acid degradation bifunctional protein | 1.7.3.3 | 1.000 | |
| 1xxj | UNC | Uricase | 1.7.3.3 | 0.487 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.467 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.466 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.464 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.461 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.461 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.460 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 2wq7 | FAD | RE11660p | / | 0.456 | |
| 4emi | NAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.456 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.454 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.453 | |
| 2e1z | B4P | Propionate kinase | / | 0.453 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.452 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.451 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.449 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 2bxo | OPB | Serum albumin | / | 0.448 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.448 | |
| 1ao0 | ADP | Amidophosphoribosyltransferase | / | 0.447 | |
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 0.447 | |
| 3eo8 | FMN | Putative nitroreductase | / | 0.447 | |
| 3rv7 | RVB | Salicylate synthase | / | 0.447 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.447 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.446 | |
| 4yqf | GDP | Septin-9 | / | 0.446 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.445 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 4bqw | QNM | Egl nine homolog 1 | / | 0.445 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.445 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.445 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.444 | |
| 4eqx | FAD | Coenzyme A disulfide reductase | / | 0.444 | |
| 4jld | ADP | Adenylate kinase | / | 0.444 | |
| 2nli | FMN | Lactate oxidase | / | 0.443 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.443 | |
| 1s4o | GDP | Glycolipid 2-alpha-mannosyltransferase | / | 0.442 | |
| 1z41 | FMN | NADPH dehydrogenase | / | 0.442 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.442 | |
| 2vwh | NAP | Glucose 1-dehydrogenase | / | 0.442 | |
| 1cq8 | PY6 | Aspartate aminotransferase | 2.6.1.1 | 0.441 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.441 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.441 | |
| 2wq6 | FAD | RE11660p | / | 0.441 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.441 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 |