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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nj32KDCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nj32KDCyclin-dependent kinase 22.7.11.221.000
2fvdLIACyclin-dependent kinase 22.7.11.220.553
3ezrEZRCyclin-dependent kinase 22.7.11.220.543
3fz1B98Cyclin-dependent kinase 22.7.11.220.543
3r7uX96Cyclin-dependent kinase 22.7.11.220.540
1aq1STUCyclin-dependent kinase 22.7.11.220.539
3le62BZCyclin-dependent kinase 22.7.11.220.512
4erwSTUCyclin-dependent kinase 22.7.11.220.506
3qqfX07Cyclin-dependent kinase 22.7.11.220.503
3sqq99ZCyclin-dependent kinase 22.7.11.220.502
3r7iX9ICyclin-dependent kinase 22.7.11.220.501
2vtqLZACyclin-dependent kinase 22.7.11.220.499
1pkdUCNCyclin-dependent kinase 22.7.11.220.498
2w05FRTCyclin-dependent kinase 22.7.11.220.498
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.497
3rak03ZCyclin-dependent kinase 22.7.11.220.496
1pxoCK7Cyclin-dependent kinase 22.7.11.220.495
2i40BLZCyclin-dependent kinase 22.7.11.220.495
4nk92K5Fibroblast growth factor receptor 1/0.495
2cchATPCyclin-dependent kinase 22.7.11.220.493
4bcqTJFCyclin-dependent kinase 22.7.11.220.493
3qx4X4BCyclin-dependent kinase 22.7.11.220.491
3qrtX14Cyclin-dependent kinase 22.7.11.220.489
3tnwF18Cyclin-dependent kinase 22.7.11.220.489
1ykr628Cyclin-dependent kinase 22.7.11.220.488
3rkb12ZCyclin-dependent kinase 22.7.11.220.488
1g5sI17Cyclin-dependent kinase 22.7.11.220.486
3rni21ZCyclin-dependent kinase 22.7.11.220.484
1w0xOLOCyclin-dependent kinase 22.7.11.220.482
4eok4SPCyclin-dependent kinase 22.7.11.220.481
3ezvEZVCyclin-dependent kinase 22.7.11.220.480
1gih1PUCyclin-dependent kinase 22.7.11.220.478
2vu3LZECyclin-dependent kinase 22.7.11.220.477
4bcmT7ZCyclin-dependent kinase 22.7.11.220.476
3s1h56ZCyclin-dependent kinase 22.7.11.220.474
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.473
2x1nX1NCyclin-dependent kinase 22.7.11.220.473
3lfqA28Cyclin-dependent kinase 22.7.11.220.473
3r9dX6BCyclin-dependent kinase 22.7.11.220.473
2c5nCK8Cyclin-dependent kinase 22.7.11.220.471
2wihP48Cyclin-dependent kinase 22.7.11.220.471
3r1sX73Cyclin-dependent kinase 22.7.11.220.471
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
2vttLZDCyclin-dependent kinase 22.7.11.220.469
3qxpX64Cyclin-dependent kinase 22.7.11.220.468
1pyePM1Cyclin-dependent kinase 22.7.11.220.467
2uzbC75Cyclin-dependent kinase 22.7.11.220.467
3ddqRRCCyclin-dependent kinase 22.7.11.220.465
3r73X87Cyclin-dependent kinase 22.7.11.220.465
3rm618ZCyclin-dependent kinase 22.7.11.220.464
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.464
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.461
1di8DTQCyclin-dependent kinase 22.7.11.220.460
1h1r6CPCyclin-dependent kinase 22.7.11.220.459
2uzeC95Cyclin-dependent kinase 22.7.11.220.459
2w17I19Cyclin-dependent kinase 22.7.11.220.457
3lfnA27Cyclin-dependent kinase 22.7.11.220.457
3qqkX02Cyclin-dependent kinase 22.7.11.220.457
3r9hZ67Cyclin-dependent kinase 22.7.11.220.457
4hvh19RTyrosine-protein kinase JAK32.7.10.20.457
3rk507ZCyclin-dependent kinase 22.7.11.220.456
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.456
3lfsA07Cyclin-dependent kinase 22.7.11.220.455
3rk708ZCyclin-dependent kinase 22.7.11.220.455
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.455
1finATPCyclin-dependent kinase 22.7.11.220.454
1oi9N20Cyclin-dependent kinase 22.7.11.220.454
4ii5ADPCyclin-dependent kinase 22.7.11.220.454
5e8wSTUTGF-beta receptor type-12.7.11.300.454
1oguST8Cyclin-dependent kinase 22.7.11.220.453
2bheBRYCyclin-dependent kinase 22.7.11.220.453
4fkr45KCyclin-dependent kinase 22.7.11.220.453
2a0cCK9Cyclin-dependent kinase 22.7.11.220.452
2wpa889Cyclin-dependent kinase 22.7.11.220.452
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.452
4ic7ANPMitogen-activated protein kinase 72.7.11.240.452
1yvj4STTyrosine-protein kinase JAK32.7.10.20.451
2bkzSBCCyclin-dependent kinase 22.7.11.220.451
2f2cAP9Cyclin-dependent kinase 62.7.11.220.451
3r8zZ63Cyclin-dependent kinase 22.7.11.220.451
2vthLZ2Cyclin-dependent kinase 22.7.11.220.450
4cd0AWJALK tyrosine kinase receptor2.7.10.10.450
4fob0USALK tyrosine kinase receptor2.7.10.10.450
4jqeANPCasein kinase II subunit alpha2.7.11.10.450
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.449
2b55D31Cyclin-dependent kinase 22.7.11.220.449
2eufLQQCyclin-dependent kinase 62.7.11.220.449
2wxvWXVCyclin-dependent kinase 22.7.11.220.449
3cr0809Wee1-like protein kinase2.7.10.20.449
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.449
3nux3NVCyclin-dependent kinase 62.7.11.220.449
3qtzX42Cyclin-dependent kinase 22.7.11.220.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4hvg19QTyrosine-protein kinase JAK32.7.10.20.449
1h1s4SPCyclin-dependent kinase 22.7.11.220.448
2ijmATPFocal adhesion kinase 12.7.10.20.448
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.448
2uzlC94Cyclin-dependent kinase 22.7.11.220.447
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.447
3qqlX03Cyclin-dependent kinase 22.7.11.220.447
3rmf20ZCyclin-dependent kinase 22.7.11.220.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.447
1fvv107Cyclin-dependent kinase 22.7.11.220.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.446
1v1k3FPCyclin-dependent kinase 22.7.11.220.446
1wvxBD4Death-associated protein kinase 12.7.11.10.446
2iw84SPCyclin-dependent kinase 22.7.11.220.446
3gxlQIGTGF-beta receptor type-12.7.11.300.446
3lltANPProtein serine/threonine kinase-1/0.446
3r7yZ04Cyclin-dependent kinase 22.7.11.220.446
4fkt48KCyclin-dependent kinase 22.7.11.220.446
1ke7LS3Cyclin-dependent kinase 22.7.11.220.445
4fks46KCyclin-dependent kinase 22.7.11.220.445
4gub0Y4Casein kinase II subunit alpha2.7.11.10.445
1e9hINRCyclin-dependent kinase 22.7.11.220.444
1v0oINRCell division control protein 2 homolog2.7.11.220.444
1vyw292Cyclin-dependent kinase 22.7.11.220.444
3ti1B49Cyclin-dependent kinase 22.7.11.220.444
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4fkw62KCyclin-dependent kinase 22.7.11.220.444
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.443
2c6tDT5Cyclin-dependent kinase 22.7.11.220.443
2xa4AZ5Tyrosine-protein kinase JAK2/0.443
3uli1N3Cyclin-dependent kinase 22.7.11.220.443
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
4acm7YGCyclin-dependent kinase 22.7.11.220.443
4bcpT3CCyclin-dependent kinase 22.7.11.220.443
4yuqKS1Calmodulin-like domain protein kinase/0.443
1ouk084Mitogen-activated protein kinase 14/0.442
1pxjCK2Cyclin-dependent kinase 22.7.11.220.442
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.442
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.442
3w2sW2REpidermal growth factor receptor2.7.10.10.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
3r1qX75Cyclin-dependent kinase 22.7.11.220.441
4fx360KCyclin-dependent kinase 22.7.11.220.441
1ke6LS2Cyclin-dependent kinase 22.7.11.220.440
2b53D23Cyclin-dependent kinase 22.7.11.220.440
2duv371Cyclin-dependent kinase 22.7.11.220.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3s1dZIRCytokinin dehydrogenase 11.5.99.120.440
4c61LMMTyrosine-protein kinase JAK2/0.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440