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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/1.000
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.663
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.652
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.632
1x1aSAMC-20 methyltransferase/0.474
1h60STRPentaerythritol tetranitrate reductase/0.468
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.467
2cekN8TAcetylcholinesterase3.1.1.70.464
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.463
4j4nD44Peptidylprolyl isomerase/0.463
2g1y5IGRenin3.4.23.150.461
2wzySQXSoluble acetylcholine receptor/0.461
3q43D66M1 family aminopeptidase3.4.110.461
4bftZVTPantothenate kinase2.7.1.330.461
4bfzZVZPantothenate kinase2.7.1.330.460
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.458
1obnASVIsopenicillin N synthase1.21.3.10.456
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.456
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.456
4nv1TYDFormyl transferase/0.456
2b58COADiamine acetyltransferase 1/0.455
2uxoTACHTH-type transcriptional regulator TtgR/0.454
2xuiTZ5Acetylcholinesterase3.1.1.70.452
1rneC60Renin3.4.23.150.451
1rftPXMPyridoxal kinase2.7.1.350.450
1xvaSAMGlycine N-methyltransferase2.1.1.200.450
2il2LIXRenin3.4.23.150.450
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4q0kGA3Phytohormone-binding protein/0.450
1h22E10Acetylcholinesterase3.1.1.70.449
3d91REMRenin3.4.23.150.449
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.448
2gv8NDPThiol-specific monooxygenase1.14.130.448
4b7zQ4QAcetylcholinesterase3.1.1.70.447
2xuoTZ4Acetylcholinesterase3.1.1.70.446
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
2qimZEAClass 10 plant pathogenesis-related protein/0.445
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4eb5PLPCysteine desulfurase IscS 2/0.445
1xe65FPPlasmepsin-23.4.23.390.444
2ikuLIYRenin3.4.23.150.444
4bfxZVXPantothenate kinase2.7.1.330.444
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2xuqTZ4Acetylcholinesterase3.1.1.70.443
4araC56Acetylcholinesterase3.1.1.70.443
1q84TZ4Acetylcholinesterase3.1.1.70.442
2g1o2IGRenin3.4.23.150.442
2g247IGRenin3.4.23.150.441
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4ey7E20Acetylcholinesterase3.1.1.70.441
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.441
2j3qTFLAcetylcholinesterase3.1.1.70.440
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.440
3qe2FMNNADPH--cytochrome P450 reductase/0.440
4m83ERYOleandomycin glycosyltransferase2.4.10.440