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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4la1FADThioredoxin glutathione reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4la1FADThioredoxin glutathione reductase/1.000
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.623
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.611
1grhFADGlutathione reductase, mitochondrial1.8.1.70.603
1fecFADTrypanothione reductase1.8.1.120.595
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.591
2hqmFADGlutathione reductase1.8.1.70.590
4dnaFADProbable glutathione reductase/0.590
1greFADGlutathione reductase, mitochondrial1.8.1.70.583
1grgFADGlutathione reductase, mitochondrial1.8.1.70.583
1tytFADTrypanothione reductase1.8.1.120.583
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.581
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.580
2jk6FADTrypanothione reductase/0.578
1febFADTrypanothione reductase1.8.1.120.570
3grsFADGlutathione reductase, mitochondrial1.8.1.70.570
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.568
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.567
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.558
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.552
4j56FADThioredoxin reductase 21.8.1.90.552
1gerFADGlutathione reductase1.8.1.70.549
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.547
2wbaFADTrypanothione reductase1.8.1.120.537
4j57FADThioredoxin reductase 21.8.1.90.537
4nevFADTrypanothione reductase/0.534
1bzlFADTrypanothione reductase1.8.1.120.524
1feaFADTrypanothione reductase1.8.1.120.520
1graFADGlutathione reductase, mitochondrial1.8.1.70.517
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.510
2r9zFADGlutathione amide reductase/0.507
1zk7FADMercuric reductase1.16.1.10.506
4jq9FADDihydrolipoyl dehydrogenase/0.505
1gxfFADTrypanothione reductase1.8.1.120.499
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.497
1typFADTrypanothione reductase1.8.1.120.495
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.494
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.492
2eq9FADDihydrolipoyl dehydrogenase/0.489
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.481
2eq6FADDihydrolipoyl dehydrogenase/0.479
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.479
4eqwFADCoenzyme A disulfide reductase/0.479
1zx9FADMercuric reductase1.16.1.10.478
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.476
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.474
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.473
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.468
2x8gFADThioredoxin glutathione reductase/0.468
2tprFADTrypanothione reductase1.8.1.120.467
2eq8FADDihydrolipoyl dehydrogenase/0.466
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.465
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.463
3ladFADDihydrolipoyl dehydrogenase/0.458
1yqzFADCoenzyme A disulfide reductase/0.457
4b1bFADThioredoxin reductase1.8.1.90.455
3ic9FADPutative dihydrolipoamide dehydrogenase/0.454
3urhFADDihydrolipoyl dehydrogenase/0.451
2wp5FADTrypanothione reductase/0.442
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.441